What it is
Apigenin is a naturally occurring flavonoid found in chamomile and celery, utilized for its calming and sleep-promoting properties. It is available in capsule form, dosed for adult use.
Supplement · Mood, Anxiety & Emotional Balance
Apigenin
500 mg · vegan · gluten-free · 90 caps
difficulty-falling-asleeprestless-sleepdaytime-fatigue brain
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How it works
Apigenin exerts its effects by binding to benzodiazepine receptors in the brain, promoting GABAergic activity, and inhibiting CD38. These actions contribute to reduced anxiety and improved sleep onset and quality.
Who should take it
Adults looking to address difficulty falling asleep, restless sleep, daytime fatigue. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How long does it take for apigenin to work?
Noticeable effects on sleep and calm are typically observed within 1-3 weeks of consistent daily dosing.
Can apigenin be taken with other supplements?
Yes, apigenin can be layered into broader protocols. However, consult a clinician if you are on prescription medications affecting similar pathways.
What is the primary benefit of apigenin?
Apigenin is primarily used to support sleep quality, promote relaxation, and reduce anxiety.
Research
6 studies · 2010–2024
Evidence grade
ABCD
C · C · emerging-to-moderate human evidence for sleep quality and relaxation
From the blog
Editorial notes
SacredBod's longer take on Apigenin — context the structured blocks above don't capture.
About Apigenin
Apigenin is a mood, anxiety & emotional balance supplement used to support sleep quality and relaxation. Chamomile/celery flavone for sleep and CD38. It is available in capsule form and dosed for adults in India and internationally. As a western-tradition entry in the SacredBod catalog, it is positioned as a single-ingredient option that can be used on its own or layered into a broader protocol. Apigenin works through the mechanisms characteristic of its class — see the mechanism and research sections for detail. It primarily acts on the brain, nervous system, and effects are dose-dependent, typically becoming measurable within 1-3 weeks for noticeable sleep and calm. Consistency matters more than dose size for this category.
Evidence
Apigenin carries an evidence grade of C in the SacredBod catalog, reflecting emerging human evidence for sleep quality and relaxation. Chamomile/celery flavone for sleep and CD38. Benefits are cumulative rather than immediate, typically becoming noticeable within 1-3 weeks for noticeable sleep and calm, and individual response varies.
Dosing
A typical dose is 500 mg, taken with food, usually in the morning. Start at the lower end, assess tolerance, and stay consistent; more is not automatically better.
Cautions
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
Who it’s for
Adults looking to address difficulty falling asleep, restless sleep, daytime fatigue. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
As part of the Mood, Anxiety & Emotional Balance category, Apigenin can be used on its own or layered into a broader protocol — see the Goes with panel for evidence-aligned pairings.
Added to your stack.