What it is
Apigenin is a naturally occurring flavonoid found in chamomile, known for its potential to improve sleep quality and promote relaxation. It is available in capsule form for adult use.
Supplement · Longevity & NAD+
Apigenin
50 mg · vegan · gluten-free · 90 caps
difficulty-falling-asleeprestless-sleepdaytime-fatigue brainliver
Affiliate link · we earn from qualifying purchases. No paid placements.
How it works
Apigenin primarily interacts with GABA receptors in the brain, promoting a calming effect. It may also inhibit CD38, an enzyme that depletes NAD+ levels, contributing to longevity pathways. Effects on sleep and calm are typically observed within 1-3 weeks of consistent use.
Who should take it
Adults looking to address difficulty falling asleep, restless sleep, daytime fatigue. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
Can apigenin be taken with other sleep aids?
Consult your clinician before combining apigenin with other sleep aids, especially prescription medications, to avoid potential interactions.
How long does it take to feel the effects of apigenin?
Noticeable improvements in sleep quality and relaxation are typically observed within 1 to 3 weeks of consistent daily dosing.
Is apigenin safe for long-term use?
Apigenin is generally considered safe at recommended doses for adults. However, long-term safety data is still evolving, and consulting with a healthcare provider is advisable for extended use.
Research
6 studies · 2010–2024
Evidence grade
ABCD
C · C · emerging-to-moderate human evidence for sleep quality and relaxation
From the blog
Editorial notes
SacredBod's longer take on Apigenin — context the structured blocks above don't capture.
About Apigenin
Apigenin is a longevity & nad+ supplement used to support sleep quality and relaxation. Chamomile flavone for sleep, calm and CD38. It is available in capsule form and dosed for adults in India and internationally. As a western-tradition entry in the SacredBod catalog, it is positioned as a single-ingredient option that can be used on its own or layered into a broader protocol. Apigenin works through the mechanisms characteristic of its class — see the mechanism and research sections for detail. It primarily acts on the brain, nervous system, and effects are dose-dependent, typically becoming measurable within 1-3 weeks for noticeable sleep and calm. Consistency matters more than dose size for this category.
Evidence
Apigenin carries an evidence grade of C in the SacredBod catalog, reflecting emerging human evidence for sleep quality and relaxation. Chamomile flavone for sleep, calm and CD38. Benefits are cumulative rather than immediate, typically becoming noticeable within 1-3 weeks for noticeable sleep and calm, and individual response varies.
Dosing
A typical dose is 50 mg, taken with food, usually in the morning. Start at the lower end, assess tolerance, and stay consistent; more is not automatically better.
Cautions
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
Who it’s for
Adults looking to address difficulty falling asleep, restless sleep, daytime fatigue. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
As part of the Longevity & NAD+ category, Apigenin can be used on its own or layered into a broader protocol — see the Goes with panel for evidence-aligned pairings.
Added to your stack.