What it is
Apigenin is a citrus/parsley flavonoid that inhibits CD38, the enzyme that degrades NAD+. Recently popularized by David Sinclair’s longevity protocol.
Supplement · Longevity & CD38 Inhibition
Apigenin (Pure)
Apigenin standardised
50–100 mg · vegan · gluten-free · 60 caps
anxietyinsomniapremature-aging liverbraincell
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How it works
CD38 inhibition raises NAD+ pools; benzodiazepine receptor binding at modest affinity supports sleep onset.
Who should take it
Midlife users stacking with NAD+ precursors, adults with mild sleep onset issues.
Avoid / careful
Coordinate with benzodiazepines and CYP1A2 substrates.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
Flexible — works in any of the above.
FAQs
Frequently asked
What is CD38 and why is inhibiting it important?
CD38 is an enzyme that breaks down NAD+, a vital coenzyme for cellular energy and repair. Inhibiting CD38 helps maintain higher NAD+ levels, which are associated with healthy aging.
Can apigenin help with sleep?
Apigenin may support sleep onset due to its mild interaction with benzodiazepine receptors, which are involved in regulating sleep and relaxation.
What other supplements are commonly stacked with apigenin?
Apigenin is often stacked with NAD+ precursors like NMN or NR as part of a longevity regimen.
Research summary
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
In-vitro CD38 inhibition is well documented; human longevity outcomes still emerging.
From the blog
Editorial notes
SacredBod's longer take on Apigenin (Pure) — context the structured blocks above don't capture.
Apigenin (Pure) is a longevity & cd38 inhibition supplement. Apigenin is a citrus/parsley flavonoid that inhibits CD38, the enzyme that degrades NAD+. Recently popularized by David Sinclair’s longevity protocol.
How it works
CD38 inhibition raises NAD+ pools; benzodiazepine receptor binding at modest affinity supports sleep onset.
Who it’s for
Midlife users stacking with NAD+ precursors, adults with mild sleep onset issues.
Dosage & timing
- Typical dose: 50–100 mg
- Best time: evening
- With food: flexible
- Expected onset: 4–8 weeks for NAD+ preservation.
India context
Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.
Safety
Coordinate with benzodiazepines and CYP1A2 substrates.
Added to your stack.