What it is
Centrophenoxine is a synthesized compound from DMAE and parachlorophenoxyacetic acid, marketed in Europe as Lucidril for age-related cognitive decline.
Supplement · Nootropic & Lipofuscin Clearance
Centrophenoxine (Lucidril)
Meclofenoxate
250–1000 mg · vegan · gluten-free · 60 caps
memory-losscognitive-impairmentdementia brain
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How it works
Crosses BBB, releasing DMAE which raises brain choline. Also clears lipofuscin — the age-pigment of "wear and tear" — from neurons.
Who should take it
Older adults with cognitive decline, midlife users targeting cellular aging in brain.
Avoid / careful
Individuals with bipolar disorder should avoid Centrophenoxine due to potential mood destabilization. Those with severe epilepsy should also refrain from its use, as it may lower the seizure threshold.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
Is Centrophenoxine safe for long-term use?
While used for decades in some regions, long-term safety data in diverse populations is limited. Consult a healthcare professional for personalized advice.
Can Centrophenoxine improve memory in younger adults?
Its primary indication is age-related cognitive decline. Effects in younger, healthy individuals are less studied and may be minimal.
What is lipofuscin?
Lipofuscin is an aggregate of oxidized proteins and lipids that accumulates in lysosomes of post-mitotic cells, such as neurons, over time. It is considered a marker of cellular aging.
Research summary
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
European trials in elderly cognitive decline at 1500 mg/day show modest benefits.
Editorial notes
SacredBod's longer take on Centrophenoxine (Lucidril) — context the structured blocks above don't capture.
Centrophenoxine (Lucidril) is a nootropic & lipofuscin clearance supplement. Centrophenoxine is a synthesized compound from DMAE and parachlorophenoxyacetic acid, marketed in Europe as Lucidril for age-related cognitive decline.
How it works
Crosses BBB, releasing DMAE which raises brain choline. Also clears lipofuscin — the age-pigment of “wear and tear” — from neurons.
Who it’s for
Older adults with cognitive decline, midlife users targeting cellular aging in brain.
Dosage & timing
- Typical dose: 250–1000 mg
- Best time: morning
- With food: with-food
- Expected onset: 4–8 weeks for cognitive markers.
India context
Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.
Safety
Bipolar disorder, severe epilepsy.
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