What it is
Fisetin is a flavonoid from strawberries with the most robust senolytic activity profile in Mayo Clinic mouse models (Yousefzadeh et al. 2018).
Supplement · Longevity & Senolytic
Fisetin (Senolytic Pulse)
Fisetin
500 mg–1500 mg in 2-day pulses (monthly) · vegan · gluten-free · 60 caps
premature-aging connective tissueblood vesselimmune system
Affiliate link · we earn from qualifying purchases. No paid placements.
How it works
Selectively triggers apoptosis in senescent cells (zombie cells) without damaging healthy cells, reducing inflammaging burden.
Who should take it
Adults 40+ doing pulsed senolytic protocols. Don’t use as continuous daily.
Avoid / careful
Pregnancy, active cancer treatment. Pulse protocol only.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
What are senescent cells?
Senescent cells are aged or damaged cells that stop dividing but do not die. They accumulate in tissues and release inflammatory signals, contributing to age-related decline.
Why is fisetin used in pulses?
Pulsed dosing is believed to be more effective for senolytic agents, allowing the body to clear senescent cells without overwhelming cellular processes or causing potential side effects from continuous exposure.
Can fisetin be taken daily?
No, fisetin is recommended for pulsed use only, typically for 2 days per month, as part of a senolytic protocol. Daily use is not advised.
Research summary
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Yousefzadeh 2018 mouse data is exceptional; human trials underway (Mayo, Kirkland).
From the blog
Editorial notes
SacredBod's longer take on Fisetin (Senolytic Pulse) — context the structured blocks above don't capture.
Fisetin (Senolytic Pulse) is a longevity & senolytic supplement. Fisetin is a flavonoid from strawberries with the most robust senolytic activity profile in Mayo Clinic mouse models (Yousefzadeh et al. 2018).
How it works
Selectively triggers apoptosis in senescent cells (zombie cells) without damaging healthy cells, reducing inflammaging burden.
Who it’s for
Adults 40+ doing pulsed senolytic protocols. Don’t use as continuous daily.
Dosage & timing
- Typical dose: 500 mg–1500 mg in 2-day pulses (monthly)
- Best time: morning
- With food: with-food
- Expected onset: Acute senolytic effect within 48 hours of pulse.
- Cycling: 2 days on, ~28 days off (pulse protocol).
India context
Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.
Safety
Pregnancy, active cancer treatment. Pulse protocol only.
Added to your stack.