1 billion CFU · vegan · gluten-free · 120 caps
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Pediococcus acidilactici is a Gram-positive lactic acid bacterium in the Lactobacillaceae family, traditionally used in fermented foods and silage preservation. It is distinguished by exceptional resistance to heat, acid and bile salts — making it one of the most robust probiotics for surviving passage through the stomach and small intestine. The R1001 strain (also called HA-6111-2) is included in several multi-strain probiotic formulations.
P. acidilactici produces bacteriocins (pediocin-like antimicrobial peptides) that inhibit pathogenic bacteria including Listeria, Salmonella and E. coli. It acidifies the intestinal lumen, creating an unfavourable environment for pathogens. The R1001 strain has demonstrated immune-modulating activity in animal models, increasing natural killer (NK) cell activity and macrophage phagocytosis. Its heat stability (survives up to 65°C) makes it ideal for shelf-stable formulations and travel.
Individuals seeking a heat-stable probiotic for travel or regions with unreliable refrigeration. Those wanting immune support from a bacteriocin-producing strain. Athletes interested in sports recovery probiotics. People with general digestive discomfort seeking robust GI survival.
Individuals with severe immunosuppression. Those with central venous catheters. People with short bowel syndrome or compromised intestinal integrity. Not for premature infants. Side effects: Generally well-tolerated. Mild bloating or gas during initial colonisation (first 1–2 weeks). Rare allergic reactions. As with all probiotics, immunocompromised individuals should consult a physician.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: PMID 18436293 (tolerance and cow's milk allergy trial with L. casei CRL431), PMID 34739535 (L. casei 431 immune regulation in URT dysbiosis), PMID 21899798 (immune benefits of L. casei 431 in vaccination model)
SacredBod's longer take on Pediococcus Acidilactici — context the structured blocks above don't capture.
Pediococcus acidilactici is a Gram-positive lactic acid bacterium in the Lactobacillaceae family, traditionally used in fermented foods and silage preservation. It is distinguished by exceptional resistance to heat, acid and bile salts — making it one of the most robust probiotics for surviving passage through the stomach and small intestine. The R1001 strain (also called HA-6111-2) is included in several multi-strain probiotic formulations.
P. acidilactici produces bacteriocins (pediocin-like antimicrobial peptides) that inhibit pathogenic bacteria including Listeria, Salmonella and E. coli. It acidifies the intestinal lumen, creating an unfavourable environment for pathogens. The R1001 strain has demonstrated immune-modulating activity in animal models, increasing natural killer (NK) cell activity and macrophage phagocytosis. Its heat stability (survives up to 65°C) makes it ideal for shelf-stable formulations and travel.
Individuals seeking a heat-stable probiotic for travel or regions with unreliable refrigeration. Those wanting immune support from a bacteriocin-producing strain. Athletes interested in sports recovery probiotics. People with general digestive discomfort seeking robust GI survival.
Typical dose: 1 billion CFU per day
Form: capsules (120 count)
Best time: morning
With food: with-food
Expected onset: 2–4 weeks for digestive benefits; 4–6 weeks for immune support
Cycling: No cycling required. Can be taken continuously.
Known side effects: Generally well-tolerated. Mild bloating or gas during initial colonisation (first 1–2 weeks). Rare allergic reactions. As with all probiotics, immunocompromised individuals should consult a physician.
Who should avoid: Individuals with severe immunosuppression. Those with central venous catheters. People with short bowel syndrome or compromised intestinal integrity. Not for premature infants.
Avoid combining with: Antibiotics (take 2 hours apart), Immunosuppressants, Antifungals (theoretical interaction)
Pediococcus Acidilactici is available on Amazon India with varying brand quality. When selecting a probiotic, verify CFU count at expiry (not just at manufacture), strain specificity and refrigeration requirements. Indian brand preferences include Tata 1mg, ZEROHARM, Carbamide Forte, HealthKart, Jarrow Formulas, Now Foods, and Meibotan. Prices vary significantly; compare cost-per-CFU rather than capsule count alone.
Schedule status in India: Not a Schedule H drug; available as dietary supplement.
Key citations: PMID 18436293 (tolerance and cow’s milk allergy trial with L. casei CRL431), PMID 34739535 (L. casei 431 immune regulation in URT dysbiosis), PMID 21899798 (immune benefits of L. casei 431 in vaccination model)
Evidence grade: C — Animal and in-vitro studies; limited human clinical trials for P. acidilactici alone
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