India has one of the highest rates of micronutrient deficiency in the world — and the supplement market is growing fast to meet it. But with hundreds of products on Amazon.in and little regulation, knowing what to actually buy is harder than it should be. This guide covers Trimethylglycine (TMG / Betaine) from first principles: what it is, what the evidence says, and how to use it safely in an Indian context.
What is Trimethylglycine (TMG / Betaine)?
Trimethylglycine (TMG, also called betaine) is a naturally occurring compound found in beets, spinach, quinoa,
Trimethylglycine (TMG / Betaine) is relevant for anyone dealing with elevated-homocysteine. It primarily acts on the liver.
How does Trimethylglycine (TMG / Betaine) work?
TMG donates one of its three methyl groups to homocysteine, producing methionine and dimethylglycine (DMG). Methionine
Who should take Trimethylglycine (TMG / Betaine)?
People with elevated homocysteine who have not responded to folate/B-12/B-6 supplementation alone. People with NAFLD
The typical dose is 500-3,000 mg per day. Divided into 2-3 doses with meals
Safety and who should avoid it
Avoid if you have a known betaine allergy (extremely rare). High doses (>3 g/day) commonly cause GI upset, diarrhea,
Always consult your doctor before starting any new supplement, particularly if you are on prescription medication or have an existing health condition.
How to combine Trimethylglycine (TMG / Betaine)
Trimethylglycine (TMG / Betaine) works well alongside vitamin b complex. The Ayurvedic tradition has long used ashwagandha ksm66 for similar purposes — these can complement rather than replace each other.
Buying guide for India
When shopping on Amazon.in, prioritise products that clearly state:
- The standardised active compound percentage
- Third-party testing (NSF, USP, or Informed Sport)
- The form of Trimethylglycine (TMG / Betaine) (extract vs whole herb vs isolate)
- Vegetarian capsule certification if that matters to you
Generic “natural” or “herbal” labels without standardisation information are a red flag. The price difference between a well-made and a poorly-made Trimethylglycine (TMG / Betaine) supplement is often small — the difference in efficacy is not.
Bottom line
Trimethylglycine (TMG / Betaine) has Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). ri for elevated-homocysteine. Used consistently at the right dose, it is a reasonable addition to a wellness protocol for those dealing with these concerns.
Supplements mentioned
Trimethylglycine (TMG / Betaine)
methylation · 500-3,000 mg per day · 120 caps
People also ask
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