What it is
Agmatine Sulfate is an amino acid derivative of L-arginine. It is used to support cardiovascular and circulatory health by influencing nitric oxide pathways and acting as a neuromodulator.
Supplement · Amino Acid
Agmatine Sulfate
750 mg · vegan · gluten-free · 90 caps
hypertensionpoor-circulationhigh cholesterol heartblood vesselkidney
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How it works
Agmatine Sulfate modulates nitric oxide synthase (NOS) activity, promoting vasodilation and improved blood flow. It also interacts with various neurotransmitter systems in the brain, contributing to its neuromodulatory effects.
Who should take it
Adults looking to address high blood pressure, poor circulation, high cholesterol. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How long does it take to see results?
Measurable cardiovascular markers typically become apparent within 4-12 weeks of consistent daily use.
Can Agmatine Sulfate be combined with other supplements?
Yes, it can be layered into a broader protocol. However, consult a clinician if you are on prescription medications affecting similar pathways.
What is the typical serving size?
A common serving size is 750 mg, taken once daily.
Research
6 studies · 2010–2024
Evidence grade
ABCD
C · C · emerging-to-moderate human evidence for cardiovascular and circulatory health
From the blog
Editorial notes
SacredBod's longer take on Agmatine Sulfate — context the structured blocks above don't capture.
About Agmatine Sulfate
Arginine metabolite for nitric-oxide tone and neuromodulation.
As part of the Amino Acid category, Agmatine Sulfate is included in the SacredBod catalog to support cardiovascular and circulatory health. See the Mechanism and Research sections above for detail.
Added to your stack.