What it is
Tributyrin is the triglyceride form of butyric acid (butyrate). The triglyceride backbone delivers butyrate intact past the stomach and small intestine into the colon.
Supplement · Gut Health & SCFA
Tributyrin (Butyrate Precursor)
Glyceryl tributyrate
500–1500 mg · vegan · gluten-free · 60 caps
inflammationulcerative-colitis gutimmune system
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How it works
Butyrate is the preferred fuel for colonocytes (colon cells) and signals anti-inflammatory pathways (HDAC inhibition, FFAR3). Restoring colonic butyrate supports the gut barrier.
Who should take it
Adults with IBS-D, mild ulcerative colitis (as adjunct), leaky-gut symptom phenotype, or post-antibiotic gut recovery.
Avoid / careful
Active IBD flares should be managed with a gastroenterologist.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
Can Tributyrin help with constipation?
Tributyrin is primarily indicated for diarrhea-predominant IBS and leaky gut symptoms. While SCFA can influence gut motility, its direct benefit for constipation is less established compared to fiber or other agents.
How long does it take to see results?
Improvements in gut symptoms may be observed within 2-4 weeks of consistent daily use, though full benefits for gut barrier repair can take longer.
Is Tributyrin safe for long-term use?
Tributyrin is generally considered safe for long-term use when taken at recommended doses. Its role as a natural fuel source for colonocytes suggests a favorable safety profile.
Research summary
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Italian IBD RCTs show fecal calprotectin reductions at 300+ mg/day over 8 weeks.
From the blog
Editorial notes
SacredBod's longer take on Tributyrin (Butyrate Precursor) — context the structured blocks above don't capture.
Tributyrin (Butyrate Precursor) is a gut health & scfa supplement. Tributyrin is the triglyceride form of butyric acid (butyrate). The triglyceride backbone delivers butyrate intact past the stomach and small intestine into the colon.
How it works
Butyrate is the preferred fuel for colonocytes (colon cells) and signals anti-inflammatory pathways (HDAC inhibition, FFAR3). Restoring colonic butyrate supports the gut barrier.
Who it’s for
Adults with IBS-D, mild ulcerative colitis (as adjunct), leaky-gut symptom phenotype, or post-antibiotic gut recovery.
Dosage & timing
- Typical dose: 500–1500 mg
- Best time: morning
- With food: with-food
- Expected onset: 2–6 weeks for IBS and inflammatory markers.
India context
Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.
Safety
Active IBD flares should be managed with a gastroenterologist.
Added to your stack.