What it is
Citrulline Malate is a compound combining the amino acid L-citrulline with malic acid. It is utilized to support nitric oxide production, which aids in vasodilation and blood flow.
Supplement · Athletic Recovery & Performance
Citrulline Malate
8 g · vegan · gluten-free · 30 caps
hypertensionpoor-circulationhigh cholesterol heartblood vesselkidney
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How it works
L-citrulline is converted to L-arginine in the kidneys, which then serves as a substrate for nitric oxide synthase. Malate contributes to the Krebs cycle, potentially enhancing energy production.
Who should take it
Adults looking to address high blood pressure, poor circulation, high cholesterol. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How long does it take to see results?
Measurable cardiovascular effects may become apparent within 4-12 weeks of consistent daily use.
Can Citrulline Malate be taken with other supplements?
Yes, it can be layered with other supplements, but consult a clinician if you are on prescription medications affecting similar pathways.
What is the difference between Citrulline and Citrulline Malate?
Citrulline Malate includes malic acid, which may offer additional benefits related to energy metabolism and ATP production, alongside the nitric oxide support from citrulline.
Research
6 studies · 2010–2024
Evidence grade
ABCD
A · A · emerging-to-moderate human evidence for cardiovascular and circulatory health
From the blog
Editorial notes
SacredBod's longer take on Citrulline Malate — context the structured blocks above don't capture.
About Citrulline Malate
Citrulline Malate is a athletic recovery & performance supplement used to support cardiovascular and circulatory health. Citrulline-malate for pumps, power and endurance. It is available in powder form and dosed for adults in India and internationally. As a western-tradition entry in the SacredBod catalog, it is positioned as a single-ingredient option that can be used on its own or layered into a broader protocol. Citrulline Malate works through the mechanisms characteristic of its class — see the mechanism and research sections for detail. It primarily acts on the heart, blood vessels, and effects are dose-dependent, typically becoming measurable within 4-12 weeks for measurable cardiovascular markers. Consistency matters more than dose size for this category.
Evidence
Citrulline Malate carries an evidence grade of A in the SacredBod catalog, reflecting strong human evidence for cardiovascular and circulatory health. Citrulline-malate for pumps, power and endurance. Benefits are cumulative rather than immediate, typically becoming noticeable within 4-12 weeks for measurable cardiovascular markers, and individual response varies.
Dosing
A typical dose is 8 g, taken with food, usually in the morning. Start at the lower end, assess tolerance, and stay consistent; more is not automatically better.
Cautions
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
Who it’s for
Adults looking to address high blood pressure, poor circulation, high cholesterol. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
As part of the Athletic Recovery & Performance category, Citrulline Malate can be used on its own or layered into a broader protocol — see the Goes with panel for evidence-aligned pairings.
Added to your stack.