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DAO (Diamine Oxidase, High) — SacredBod supplement bottle (illustrative)
Supplement · Enzyme & Histamine

DAO (Diamine Oxidase, High)

20000 HDU · vegan · gluten-free · 60 caps

histamine-intoleranceheadachedull-skin gutstomach
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What it is

DAO (Diamine Oxidase, High) is a enzyme & histamine supplement. High-unit diamine oxidase (DAO) supplements the gut enzyme that degrades dietary histamine, for histamine-intolerant people. Used in adult dosing protocols in India and internationally, it is sold as a single-ingredient supplement.

How it works

Taken before histamine-rich meals, DAO breaks down ingested histamine in the gut before absorption, reducing headaches, flushing, hives and digestive symptoms. Effects are dose-dependent and typically measurable within acute, same meal.

Who should take it

Adults with histamine intolerance reacting to aged/fermented foods, wine and leftovers.

Avoid / careful

Take 15 minutes before meals. Doesn't treat mast-cell histamine release (only dietary). Porcine-derived forms.

When to take it

Morning
Noon
Evening
Night

How to take it

With food
Empty stomach
Before food

FAQs

Frequently asked

What is HDU?
HDU stands for Histamine Degrading Units, a measure of the enzyme's activity in breaking down histamine.
Can this help with all histamine reactions?
No, DAO primarily addresses histamine from dietary sources and does not manage histamine released by the body's own mast cells.
How quickly do effects occur?
Effects are typically noticeable within the same meal, as the enzyme acts on ingested histamine before absorption.

Editorial notes

SacredBod's longer take on DAO (Diamine Oxidase, High) — context the structured blocks above don't capture.

About DAO (Diamine Oxidase, High)

High-unit diamine oxidase to break down dietary histamine before meals..

How it works

Taken before histamine-rich meals, DAO breaks down ingested histamine in the gut before absorption, reducing headaches, flushing, hives and digestive symptoms. Effects are dose-dependent and typically measurable within acute, same meal.

Who it’s for

Adults with histamine intolerance reacting to aged/fermented foods, wine and leftovers.

Dosage & timing

  • Typical dose: 20000 HDU
  • Best time: morning
  • With food: before-food
  • Expected onset: Acute, same meal.

Safety

Take 15 minutes before meals. Doesn’t treat mast-cell histamine release (only dietary). Porcine-derived forms.

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