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Diindolylmethane (DIM) — SacredBod supplement bottle (illustrative)
Supplement · Hormonal & Estrogen Metabolism

Diindolylmethane (DIM)

DIM

100–200 mg microencapsulated · vegan · gluten-free · 60 caps

hormonal imbalanceskin-breakoutspms liveradrenal glandthyroid gland
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Overview Stacks Timing Related Research FAQs Blog

What it is

DIM is the stable in-vivo product of indole-3-carbinol (I3C) from cruciferous vegetables. Microencapsulation overcomes its poor solubility.

How it works

DIM upregulates CYP1A1, shifting estrogen metabolism toward 2-hydroxyestrone (protective) over 16α-hydroxyestrone (proliferative).

Who should take it

Women with estrogen-dominance phenotypes (PMS, cyclical acne), men with high estradiol on TRT, midlife hormonal balance.

Avoid / careful

Coordinate with hormonal therapy and aromatase inhibitors.

When to take it

Morning
Noon
Evening
Night

How to take it

With food
Empty stomach
Before food

FAQs

Frequently asked

Can DIM help with PMS symptoms?
Yes, DIM can help manage PMS symptoms by promoting a healthier estrogen metabolism, shifting it towards the less proliferative 2-hydroxyestrone pathway.
Is DIM safe for men?
DIM can be beneficial for men, particularly those on testosterone replacement therapy (TRT) with elevated estradiol levels, helping to normalize hormone balance.
How long does it take to see results from DIM?
Individual responses vary, but noticeable effects on hormonal balance and related symptoms may be observed within 2-4 weeks of consistent use.

Research summary

A plain-English read of the literature behind this supplement. Not a clinical recommendation.

Bradlow body of work; multiple human urinary metabolite trials show 2-OH ratio improvements.

From the blog

· 8 min read

Diindolylmethane (DIM) for Estrogen Dominance Symptoms: Does It Help?

Using Diindolylmethane (DIM) for estrogen dominance symptoms: the rationale, how to dose it for this goal, and how to track results.

#estrogen-dominance-symptoms#hormonal#use-case
· 8 min read

Diindolylmethane (DIM) vs Calcium D-Glucarate: Which Should You Choose?

Diindolylmethane (DIM) vs Calcium D-Glucarate — how they compare on mechanism, use cases, and who each one suits best.

#comparison#hormonal#guide
· 8 min read

Diindolylmethane (DIM) Dosage: How Much Should You Take?

How much Diindolylmethane (DIM) to take, when to take it, which form is best, and how to stack it safely.

#dosage#how-to#hormonal

Editorial notes

SacredBod's longer take on Diindolylmethane (DIM) — context the structured blocks above don't capture.

Diindolylmethane (DIM) is a hormonal & estrogen metabolism supplement. DIM is the stable in-vivo product of indole-3-carbinol (I3C) from cruciferous vegetables. Microencapsulation overcomes its poor solubility.

How it works

DIM upregulates CYP1A1, shifting estrogen metabolism toward 2-hydroxyestrone (protective) over 16α-hydroxyestrone (proliferative).

Who it’s for

Women with estrogen-dominance phenotypes (PMS, cyclical acne), men with high estradiol on TRT, midlife hormonal balance.

Dosage & timing

  • Typical dose: 100–200 mg microencapsulated
  • Best time: morning
  • With food: with-food
  • Expected onset: 4–8 weeks for hormonal markers.

India context

Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.

Safety

Coordinate with hormonal therapy and aromatase inhibitors.

Added to your stack.