What it is
I3C is the direct phytochemical from cruciferous vegetables. Stomach acid converts a portion to DIM, but I3C also has independent receptor effects.
Supplement · Hormonal & Estrogen Metabolism
Indole-3-Carbinol (I3C)
I3C
200–400 mg · vegan · gluten-free · 60 caps
hormonal imbalanceskin-breakoutspms liveruterusreproductive system
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How it works
I3C activates aryl hydrocarbon receptor, modulating CYP enzymes and shifting estrogen metabolism. Some metabolites are converted to DIM in the stomach.
Who should take it
Similar to DIM users — pick one. I3C is older form; DIM is more standardised.
Avoid / careful
Avoid concurrent use with aromatase inhibitors, as it may interfere with their action. Contraindicated during pregnancy due to potential hormonal effects.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
Is I3C the same as DIM?
I3C is a precursor to DIM, with a portion converting in the stomach. I3C also has independent effects.
Can I take I3C with DIM?
It is generally recommended to choose either I3C or DIM, not both, to avoid excessive intake and potential side effects.
How long does it take to see effects?
Effects can vary, but noticeable changes in hormonal balance symptoms may be observed within 4-8 weeks of consistent use.
Research summary
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
NIH cervical dysplasia trials at 400 mg/day showed regression in some cases.
From the blog
Editorial notes
SacredBod's longer take on Indole-3-Carbinol (I3C) — context the structured blocks above don't capture.
Indole-3-Carbinol (I3C) is a hormonal & estrogen metabolism supplement. I3C is the direct phytochemical from cruciferous vegetables. Stomach acid converts a portion to DIM, but I3C also has independent receptor effects.
How it works
I3C activates aryl hydrocarbon receptor, modulating CYP enzymes and shifting estrogen metabolism. Some metabolites are converted to DIM in the stomach.
Who it’s for
Similar to DIM users — pick one. I3C is older form; DIM is more standardised.
Dosage & timing
- Typical dose: 200–400 mg
- Best time: morning
- With food: with-food
- Expected onset: 4–8 weeks.
India context
Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.
Safety
Coordinate with aromatase inhibitors. Pregnancy.
Added to your stack.