What it is
Fisetin (Novusetin) is a senolytic flavonoid supplement designed to target cellular senescence and support healthy ageing. It is available in capsule form and is a single-ingredient option for targeted cellular support.
Supplement · Longevity & NAD+
Fisetin (Novusetin)
500 mg · vegan · gluten-free · 90 caps
premature-agingoxidative stresscellular-stress mitochondriacell
Affiliate link · we earn from qualifying purchases. No paid placements.
How it works
Fisetin acts as a senolytic, selectively clearing senescent cells that accumulate with age. It also influences mitochondrial health and telomere maintenance, contributing to cellular longevity. Effects on longevity markers are typically observed within 8-12 weeks of consistent use.
Who should take it
Adults looking to address premature ageing, low energy, cellular stress. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How does Fisetin clear senescent cells?
Fisetin induces apoptosis (programmed cell death) in senescent cells, which are cells that have stopped dividing and can contribute to inflammation and tissue dysfunction.
What is the difference between Fisetin and Novusetin?
Novusetin is a specific, patented form of Fisetin, often standardized for purity and bioavailability, making it a common brand name for Fisetin supplements.
Can Fisetin be taken with other supplements?
Yes, Fisetin can be layered into a broader protocol. However, consult a healthcare provider if you are on prescription medications or have specific health conditions.
Research
6 studies · 2010–2024
Evidence grade
ABCD
C · C · emerging-to-moderate human evidence for healthy ageing and cellular longevity
From the blog
Editorial notes
SacredBod's longer take on Fisetin (Novusetin) — context the structured blocks above don't capture.
About Fisetin (Novusetin)
Fisetin (Novusetin) is a longevity & nad+ supplement used to support healthy ageing and cellular longevity. Senolytic flavonoid for healthy ageing. It is available in capsule form and dosed for adults in India and internationally. As a western-tradition entry in the SacredBod catalog, it is positioned as a single-ingredient option that can be used on its own or layered into a broader protocol. Fisetin (Novusetin) works through the mechanisms characteristic of its class — see the mechanism and research sections for detail. It primarily acts on the mitochondria, cells, telomeres, and effects are dose-dependent, typically becoming measurable within 8-12 weeks for longevity markers. Consistency matters more than dose size for this category.
Evidence
Fisetin (Novusetin) carries an evidence grade of C in the SacredBod catalog, reflecting emerging human evidence for healthy ageing and cellular longevity. Senolytic flavonoid for healthy ageing. Benefits are cumulative rather than immediate, typically becoming noticeable within 8-12 weeks for longevity markers, and individual response varies.
Dosing
A typical dose is 500 mg, taken with food, usually in the morning. Start at the lower end, assess tolerance, and stay consistent; more is not automatically better.
Cautions
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
Who it’s for
Adults looking to address premature ageing, low energy, cellular stress. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
As part of the Longevity & NAD+ category, Fisetin (Novusetin) can be used on its own or layered into a broader protocol — see the Goes with panel for evidence-aligned pairings.
Added to your stack.