What it is
Hu Zhang, derived from the root of Polygonum cuspidatum (Japanese knotweed), is a potent source of resveratrol. It is utilized for its potential to support cellular health and healthy aging processes.
Supplement · Longevity & NAD+
Hu Zhang (Polygonum cuspidatum)
500 mg · vegan · gluten-free · 90 caps
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How it works
It functions by activating sirtuins, a class of proteins involved in cellular regulation and DNA repair, and by influencing mitochondrial function. These actions contribute to cellular resilience and longevity.
Who should take it
Adults looking to address premature ageing, low energy, cellular stress. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How long does it take to see effects?
Measurable effects on longevity markers typically become apparent within 8-12 weeks of consistent daily use.
Can Hu Zhang be taken with other supplements?
Yes, it can be layered into a broader protocol. However, consult a healthcare professional if you are on prescription medication affecting similar pathways.
What is the primary active compound?
The primary active compound is resveratrol, a polyphenol known for its antioxidant and cellular protective properties.
Research
6 studies · 2010–2024
Evidence grade
ABCD
C · C · emerging-to-moderate human evidence for healthy ageing and cellular longevity
From the blog
Editorial notes
SacredBod's longer take on Hu Zhang (Polygonum cuspidatum) — context the structured blocks above don't capture.
About Hu Zhang (Polygonum cuspidatum)
Hu Zhang (Polygonum cuspidatum) is a longevity & nad+ supplement used to support healthy ageing and cellular longevity. Knotweed root, a key resveratrol source. It is available in capsule form and dosed for adults in India and internationally. As a tcm-tradition entry in the SacredBod catalog, it is positioned as a single-ingredient option that can be used on its own or layered into a broader protocol. Hu Zhang (Polygonum cuspidatum) works through the mechanisms characteristic of its class — see the mechanism and research sections for detail. It primarily acts on the mitochondria, cells, telomeres, and effects are dose-dependent, typically becoming measurable within 8-12 weeks for longevity markers. Consistency matters more than dose size for this category.
Evidence
Hu Zhang (Polygonum cuspidatum) carries an evidence grade of C in the SacredBod catalog, reflecting emerging human evidence for healthy ageing and cellular longevity. Knotweed root, a key resveratrol source. Benefits are cumulative rather than immediate, typically becoming noticeable within 8-12 weeks for longevity markers, and individual response varies.
Dosing
A typical dose is 500 mg, taken with food, usually in the morning. Start at the lower end, assess tolerance, and stay consistent; more is not automatically better.
Cautions
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
Who it’s for
Adults looking to address premature ageing, low energy, cellular stress. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
As part of the Longevity & NAD+ category, Hu Zhang (Polygonum cuspidatum) can be used on its own or layered into a broader protocol — see the Goes with panel for evidence-aligned pairings.
Added to your stack.