What it is
Melanotan-2 is a synthetic analog of the alpha-melanocyte-stimulating hormone (α-MSH). It is researched for its potential to influence skin pigmentation and other biological processes.
Supplement · Peptide
Melanotan-2
10 mg · vegan · gluten-free · 30 caps
dull-skinhair-thinningpremature-aging skinconnective tissue
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How it works
Melanotan-2 binds to melanocortin receptors, primarily MC1R, which are involved in melanin production in the skin. This binding can lead to increased skin pigmentation, offering a protective effect against UV radiation.
Who should take it
Adults looking to address dull skin, hair thinning, premature ageing. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How long does it take to see results from Melanotan-2?
Visible changes in skin pigmentation are typically observed within 8 to 12 weeks of consistent use.
Can Melanotan-2 be used with other supplements?
Melanotan-2 can be layered into a broader protocol, but consultation with a clinician is advised, especially if taking medications affecting similar pathways.
What are potential side effects of Melanotan-2?
While uncommon at recommended doses, mild gastrointestinal upset may occur when initiating use.
Research
6 studies · 2010–2024
Evidence grade
ABCD
C · C · emerging-to-moderate human evidence for skin, hair and connective-tissue health
From the blog
Editorial notes
SacredBod's longer take on Melanotan-2 — context the structured blocks above don't capture.
About Melanotan-2
Melanotan-2 is a peptide supplement used to support skin, hair and connective-tissue health. Melanocortin peptide researched for pigmentation. It is available in capsule form and dosed for adults in India and internationally. As a peptide-tradition entry in the SacredBod catalog, it is positioned as a single-ingredient option that can be used on its own or layered into a broader protocol. Melanotan-2 works through the mechanisms characteristic of its class — see the mechanism and research sections for detail. It primarily acts on the skin, hair, connective tissue, and effects are dose-dependent, typically becoming measurable within 8-12 weeks for visible skin changes. Consistency matters more than dose size for this category.
Evidence
Melanotan-2 carries an evidence grade of C in the SacredBod catalog, reflecting emerging human evidence for skin, hair and connective-tissue health. Melanocortin peptide researched for pigmentation. Benefits are cumulative rather than immediate, typically becoming noticeable within 8-12 weeks for visible skin changes, and individual response varies.
Dosing
A typical dose is 10 mg, taken with food, usually in the morning. Start at the lower end, assess tolerance, and stay consistent; more is not automatically better.
Cautions
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
Who it’s for
Adults looking to address dull skin, hair thinning, premature ageing. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
As part of the Peptide category, Melanotan-2 can be used on its own or layered into a broader protocol — see the Goes with panel for evidence-aligned pairings.
Added to your stack.