What it is
MOTS-c is a mitochondrial-derived peptide researched for its role in metabolic and blood-sugar health. It is available in capsule form for adult use.
Supplement · Peptide
MOTS-c
10 mg · vegan · gluten-free · 30 caps
insulin resistanceweight-gainfatigue pancreaslivermuscle
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How it works
MOTS-c acts on the pancreas, liver, and muscle to improve insulin sensitivity and glucose metabolism. Effects on metabolic markers are typically observed within 8-12 weeks of consistent use.
Who should take it
Adults looking to address insulin resistance, weight gain, low energy. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How long does it take to see effects from MOTS-c?
Metabolic markers typically show measurable changes within 8-12 weeks of consistent daily dosing.
Can MOTS-c be combined with other supplements?
Yes, MOTS-c can be layered into a broader protocol. However, consult a healthcare professional if you are on prescription medications affecting metabolic pathways.
What is the typical serving size for MOTS-c?
The standard dose is 10 mg per day.
Research
6 studies · 2010–2024
Evidence grade
ABCD
C · C · emerging-to-moderate human evidence for metabolic and blood-sugar health
Editorial notes
SacredBod's longer take on MOTS-c — context the structured blocks above don't capture.
About MOTS-c
MOTS-c is a peptide supplement used to support metabolic and blood-sugar health. Mitochondrial-derived peptide researched for metabolism. It is available in capsule form and dosed for adults in India and internationally. As a peptide-tradition entry in the SacredBod catalog, it is positioned as a single-ingredient option that can be used on its own or layered into a broader protocol.
How it works
MOTS-c works through the mechanisms characteristic of its class — see the mechanism and research sections for detail. It primarily acts on the pancreas, liver, muscle, and effects are dose-dependent, typically becoming measurable within 8-12 weeks for metabolic markers. Consistency matters more than dose size for this category.
Who it’s for
Adults looking to address insulin resistance, weight gain, low energy. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Evidence
MOTS-c carries an evidence grade of C in the SacredBod catalog. Mitochondrial-derived peptide researched for metabolism. See the Research panel above for the underlying studies, participant counts and typical effect sizes.
Dosing & timing
Typical label dose is 10 mg in capsule form. Most adults can expect noticeable effects within 8-12 weeks for metabolic markers. Consistency matters more than a single large dose — take it daily and re-evaluate against your blood markers at 8–12 weeks.
Cautions
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
As part of the Peptide category, MOTS-c can be used on its own or layered into a broader protocol — see the Goes with panel for synergistic pairings.
Added to your stack.