What it is
MOTS-c is a mitochondrial-derived peptide researched for its role in metabolic health and blood sugar regulation. It is available in capsule form for adult use.
Supplement · Peptide
MOTS-c
10 mg · vegan · gluten-free · 30 caps
insulin resistanceweight-gainfatigue pancreaslivermuscle
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How it works
MOTS-c influences cellular energy metabolism by acting on key metabolic tissues like the pancreas, liver, and muscle. Its effects on metabolic markers are typically observed within 8-12 weeks of consistent use.
Who should take it
Adults looking to address insulin resistance, weight gain, low energy. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How long does it take to see effects from MOTS-c?
Metabolic markers typically show measurable changes within 8-12 weeks of consistent daily dosing.
Can MOTS-c be taken with other supplements?
Yes, MOTS-c can be layered into a broader protocol. However, consult a healthcare professional if you are on prescription medications affecting metabolic pathways.
What is the recommended dosage for MOTS-c?
The standard recommended dose is 10 mg per day.
Research
6 studies · 2010–2024
Evidence grade
ABCD
C · C · emerging-to-moderate human evidence for metabolic and blood-sugar health
From the blog
Editorial notes
SacredBod's longer take on MOTS-c — context the structured blocks above don't capture.
About MOTS-c
MOTS-c is a peptide supplement used to support metabolic and blood-sugar health. Mitochondrial peptide researched for metabolism. It is available in capsule form and dosed for adults in India and internationally. As a peptide-tradition entry in the SacredBod catalog, it is positioned as a single-ingredient option that can be used on its own or layered into a broader protocol. MOTS-c works through the mechanisms characteristic of its class — see the mechanism and research sections for detail. It primarily acts on the pancreas, liver, muscle, and effects are dose-dependent, typically becoming measurable within 8-12 weeks for metabolic markers. Consistency matters more than dose size for this category.
Evidence
MOTS-c carries an evidence grade of C in the SacredBod catalog, reflecting emerging human evidence for metabolic and blood-sugar health. Mitochondrial peptide researched for metabolism. Benefits are cumulative rather than immediate, typically becoming noticeable within 8-12 weeks for metabolic markers, and individual response varies.
Dosing
A typical dose is 10 mg, taken with food, usually in the morning. Start at the lower end, assess tolerance, and stay consistent; more is not automatically better.
Cautions
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
Who it’s for
Adults looking to address insulin resistance, weight gain, low energy. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
As part of the Peptide category, MOTS-c can be used on its own or layered into a broader protocol — see the Goes with panel for evidence-aligned pairings.
Added to your stack.