What it is
Immediate-release niacin (Vitamin B3) is a water-soluble vitamin supplement used to improve lipid profiles. It is available in tablet form and is dosed for adults.
Supplement · Vitamin
Niacin (Flush)
500 mg · vegan · gluten-free · 100 caps
dyslipidemiaperipheral-artery-diseaseatherosclerosis liverblood vesselheart
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How it works
Niacin works by inhibiting the enzyme diacylglycerol acyltransferase-2 (DGAT2) in the liver, reducing triglyceride synthesis and VLDL secretion. It also increases lipoprotein lipase (LPL) activity, promoting triglyceride hydrolysis. At higher doses, it can increase HDL cholesterol by reducing hepatic uptake of HDL particles and increasing apoA-I production.
Who should take it
Adults looking to address high blood pressure, poor circulation, high cholesterol. Particularly relevant for people who prefer a targeted single ingredient and who have ruled out an underlying condition that needs medical care first.
Avoid / careful
Pregnant or nursing women without clinician oversight. People on prescription medication affecting the same pathway should consult a doctor before combining. Side effects are uncommon at recommended doses but mild GI upset can occur when starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
What is the niacin flush?
The niacin flush is a common, temporary side effect of immediate-release niacin, characterized by redness, warmth, itching, or tingling of the skin. It is harmless and usually subsides within 30-60 minutes.
Can I take niacin with statins?
Combining niacin with statins should only be done under the strict supervision of a healthcare professional due to potential additive effects and increased risk of side effects.
How long does it take for niacin to affect cholesterol levels?
Significant changes in lipid markers typically become measurable within 4 to 12 weeks of consistent daily dosing.
Research
6 studies · 2010–2024
Evidence grade
ABCD
A · A · emerging-to-moderate human evidence for cardiovascular and circulatory health
From the blog
Editorial notes
SacredBod's longer take on Niacin (Flush) — context the structured blocks above don't capture.
About Niacin (Flush)
Immediate-release niacin for lipid and HDL support.
As part of the Vitamin category, Niacin (Flush) is included in the SacredBod catalog to support cardiovascular and circulatory health. See the Mechanism and Research sections above for detail.
Added to your stack.