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Noopept Cognitive Peptide — SacredBod supplement bottle (illustrative)
Supplement · Cognitive Ageing & Neuroprotection

Noopept Cognitive Peptide

20 mg · gluten-free · 30 caps

Cognitive declinePoor memory recallMental fatigueAnxiety-related cognitive impairmentPost-stroke cognitive deficits BrainHippocampusCerebral cortex
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Overview Stacks Timing Related Research FAQs

What it is

Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester) is a synthetic dipeptide nootropic developed in Russia in 1996. It is a prodrug of cycloprolylglycine, an endogenous neuropeptide. Unlike racetams, Noopept is active at microgram doses (10–30mg) and has demonstrated neuroprotective, anxiolytic, and cognitive-enhancing effects in Russian clinical trials.

How it works

Noopept modulates AMPA and NMDA glutamate receptors, increases BDNF and NGF expression in the hippocampus, and exerts anti-inflammatory and antioxidant effects in the brain. It also enhances alpha and beta brainwave activity and improves cerebral blood flow. The cycloprolylglycine metabolite is thought to be the primary active mediator.

Who should take it

Individuals with mild cognitive impairment (particularly post-stroke), those seeking rapid cognitive enhancement, and experienced nootropic users comfortable with unscheduled research compounds.

Avoid / careful

Pregnant or breastfeeding women; individuals with hypertension; those with severe kidney or liver disease; minors under 18. Side effects: Generally well tolerated. Rare irritability, insomnia, headache, or increased blood pressure. Transient fatigue upon discontinuation.

When to take it

Morning
Noon
Evening
Night

How to take it

With food
Empty stomach
Before food

FAQs

Frequently asked

How does Noopept compare to piracetam?
Noopept is approximately 1,000× more potent by weight than piracetam. It is active at 10–30mg vs 1,200–4,800mg for piracetam. Noopept also has distinct neurotrophic (BDNF/NGF) effects that piracetam lacks.
Is it legal in India?
Noopept is not scheduled under India's Narcotic Drugs and Psychotropic Substances Act, nor is it approved by CDSCO (Central Drugs Standard Control Organisation). It exists in a grey area — sold as a 'research compound' or nootropic supplement by some online vendors. Import for personal use in small quantities is generally tolerated but not guaranteed.
Can I take it daily long-term?
Russian protocols typically use 8-week cycles followed by a break. While no serious long-term toxicity has been reported, the lack of large-scale safety data warrants cycling. Do not use continuously for more than 3 months without a 4-week break.

In plain English

A plain-English read of the literature behind this supplement. Not a clinical recommendation.

Key citations: PMID 22500312 (Noopept in mild cognitive impairment post-stroke — Amelin et al.), PMID 22747190 (complementary nootropic systematic review), PMID 3153866 (complementary bacopa evidence)

Editorial notes

SacredBod's longer take on Noopept Cognitive Peptide — context the structured blocks above don't capture.

What Noopept Is

Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester) is a synthetic dipeptide nootropic developed by the Russian Academy of Medical Sciences in 1996. It is structurally related to the endogenous neuropeptide cycloprolylglycine and is considered a next-generation compound following the racetam family (piracetam, aniracetam, etc.).

Unlike racetams that require gram-level doses, Noopept is pharmacologically active at microgram doses (10–30mg/day). This high potency, combined with its neurotrophic and neuroprotective profile, has made it popular in the global nootropic community — though its regulatory status remains ambiguous in most countries, including India.

How It Works

  1. Glutamate receptor modulation — Noopept enhances signalling at AMPA and NMDA receptors, increasing synaptic plasticity and long-term potentiation (LTP).
  2. Neurotrophic factor induction — Animal and human studies demonstrate increased BDNF and NGF mRNA expression in the hippocampus, supporting neurogenesis and synaptic repair.
  3. Anti-inflammatory & antioxidant — Noopept reduces IL-6 and TNF-α in the brain and upregulates antioxidant enzymes.
  4. Cerebrovascular enhancement — Increases cerebral blood flow and oxygen utilisation, similar to vinpocetine.
  5. Brainwave modulation — EEG studies show increased alpha and beta activity, correlating with improved focus and cognitive processing speed.

Who Benefits Most

  • Post-stroke cognitive impairment — The Amelin trial showed significant MMSE improvements in stroke patients after 2 months of 20mg/day.
  • Mild cognitive impairment — Russian open-label studies report improvements in attention, memory, and mental processing speed.
  • Experienced nootropic users — Those who have exhausted basic choline/racetam stacks and seek a more potent, neurotrophic compound.
  • Not recommended for: Beginners, pregnant women, individuals with hypertension, or anyone under 18.

Dosage Guide

GoalDoseDuration
Cognitive enhancement10–20 mg/day8 weeks on, 2–4 weeks off
Post-stroke MCI (clinical protocol)20 mg/day2 months
General nootropic support10 mg/day8 weeks on, 2–4 weeks off

Take with food to minimise GI irritation. Sublingual administration (dissolving powder under the tongue) may increase absorption but tastes bitter.

Safety & Interactions

  • Hypertension: May mildly increase blood pressure; monitor if hypertensive.
  • Insomnia: Due to its mild stimulatory effect; avoid evening doses.
  • Irritability: Some users report increased emotional reactivity; reduce dose if this occurs.
  • Withdrawal: Mild fatigue or brain fog upon cessation after prolonged use; taper down over 1 week.

India-Specific Context

  • Legal status: Noopept is not approved by CDSCO and is not listed in India’s drug schedules. It is occasionally sold by Indian supplement vendors as a “research chemical” or imported via grey-market channels. Personal import risk: Small quantities for personal use are generally tolerated by Indian customs, but seizures can occur.
  • Availability: No legitimate standalone Noopept capsules are reliably available on Amazon.in. The A2Z Laboratories powder listing appears intermittently. Most “Noopept” products in India are pre-workout blends with undisclosed doses.
  • Ayurvedic parallel: There is no classical Ayurvedic equivalent to Noopept. The closest conceptual parallel is Rasayana therapy for rejuvenating mental faculties, but the mechanism (synthetic dipeptide) is entirely modern.
  • Cost: When available, 10g of Noopept powder costs ₹3,000–₹4,000 on Indian grey-market sites — enough for ~500 doses at 20mg/day.
  • Recommendation: Due to regulatory ambiguity and limited India-specific availability, we list this as TBD for Amazon.in and advise users to consult a physician before sourcing.
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