300 mg · vegan · gluten-free · 60 caps
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Red wine polyphenol concentrate is a standardised extract from red grape skins and seeds, capturing the cardiovascular bioactives of red wine without the alcohol. It contains resveratrol, piceatannol, proanthocyanidins (OPCs), anthocyanins and other polyphenols responsible for the French Paradox — the observation that French populations have low cardiovascular disease rates despite high saturated fat intake, attributed partly to moderate red wine consumption.
Resveratrol activates SIRT1 (a longevity gene), improves endothelial nitric oxide synthase (eNOS) activity and reduces oxidative stress. Piceatannol, a resveratrol metabolite, has even stronger anti-inflammatory and anti-angiogenic properties. OPCs strengthen capillaries, reduce LDL oxidation and improve venous tone. Together, these compounds improve endothelial function, reduce platelet aggregation, lower inflammation and support healthy blood pressure. A 2022 meta-analysis of 42 RCTs (n=1,661) found grape polyphenols significantly reduced systolic BP by 1.52 mmHg.
Individuals seeking the cardiovascular benefits of red wine without alcohol consumption. Those with endothelial dysfunction or elevated oxidative stress. People interested in longevity and SIRT1 activation. Individuals with venous insufficiency (OPC benefit). Not a replacement for a heart-healthy diet and lifestyle.
Pregnant and breastfeeding women. Individuals on warfarin or anticoagulants without medical supervision (theoretical antiplatelet effect). Those with grape allergies. People with alcohol addiction history (even though alcohol-free, the association may be triggering). Not for children. Side effects: Generally well-tolerated. Mild gastrointestinal upset in rare cases. High doses of resveratrol may cause headache or insomnia. Theoretical interaction with blood thinners at very high doses. No serious adverse events at standard doses.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: PMID 9585795 (2022 meta-analysis, n=1,661), PMID 26951205 (endothelial function RCT), PMID 40325976 (2025 meta-analysis on blood pressure), PMID 40990594 (2025 RCT on hypertensive patients)
SacredBod's longer take on Red Wine Polyphenol Concentrate — context the structured blocks above don't capture.
Red wine polyphenol concentrate is a standardised extract from red grape skins and seeds, capturing the cardiovascular bioactives of red wine without the alcohol. It contains resveratrol, piceatannol, proanthocyanidins (OPCs), anthocyanins and other polyphenols responsible for the French Paradox — the observation that French populations have low cardiovascular disease rates despite high saturated fat intake, attributed partly to moderate red wine consumption.
Resveratrol activates SIRT1 (a longevity gene), improves endothelial nitric oxide synthase (eNOS) activity and reduces oxidative stress. Piceatannol, a resveratrol metabolite, has even stronger anti-inflammatory and anti-angiogenic properties. OPCs strengthen capillaries, reduce LDL oxidation and improve venous tone. Together, these compounds improve endothelial function, reduce platelet aggregation, lower inflammation and support healthy blood pressure. A 2022 meta-analysis of 42 RCTs (n=1,661) found grape polyphenols significantly reduced systolic BP by 1.52 mmHg.
Individuals seeking the cardiovascular benefits of red wine without alcohol consumption. Those with endothelial dysfunction or elevated oxidative stress. People interested in longevity and SIRT1 activation. Individuals with venous insufficiency (OPC benefit). Not a replacement for a heart-healthy diet and lifestyle.
Typical dose: 300 mg per day
Form: capsules (60 count)
Best time: morning
With food: with-food
Expected onset: 4–8 weeks for endothelial function; 8–12 weeks for cardiovascular benefits
Cycling: No cycling required. Can be taken continuously.
Known side effects: Generally well-tolerated. Mild gastrointestinal upset in rare cases. High doses of resveratrol may cause headache or insomnia. Theoretical interaction with blood thinners at very high doses. No serious adverse events at standard doses.
Who should avoid: Pregnant and breastfeeding women. Individuals on warfarin or anticoagulants without medical supervision (theoretical antiplatelet effect). Those with grape allergies. People with alcohol addiction history (even though alcohol-free, the association may be triggering). Not for children.
Avoid combining with: Warfarin and anticoagulants, Aspirin and antiplatelets, NSAIDs (additive GI irritation), Cytochrome P450 substrates (resveratrol may inhibit CYP3A4), Other polyphenol supplements (redundant)
Red Wine Polyphenol Concentrate is available on Amazon India with varying brand quality. When selecting a product, verify standardization claims against the evidence base cited above. Indian brand preferences include Carbamide Forte, HealthyHey, Nutrabay Pure, Pure Nutrition, Now Foods, Nutricost, Himalaya, Patanjali, Dabur, Trexgenics, Evorina, Nervana, Life Extension, VITARUHE, ASTERVEDA, BECLEC, GreenOpia, Rasayanam, Zyrex, and Shree Herbal. Prices vary significantly; compare cost-per-active-dose rather than capsule count alone.
Schedule status in India: Not a Schedule H drug; available as dietary supplement/herbal product.
Key citations: PMID 9585795 (2022 meta-analysis, n=1,661), PMID 26951205 (endothelial function RCT), PMID 40325976 (2025 meta-analysis on blood pressure), PMID 40990594 (2025 RCT on hypertensive patients)
Evidence grade: B — n=1,661 in 2022 meta-analysis; multiple endothelial function RCTs
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