500 mg · vegan · gluten-free · 30 caps
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Alpha-ketoglutarate (AKG) is a key intermediate in the Krebs (TCA) cycle and a critical regulator of nitrogen metabolism. As a supplement, it has gained attention for its ability to reverse epigenetic aging markers and extend healthspan in animal models. This is the pure (non-calcium-bound) form, distinct from calcium-AKG.
AKG serves as a substrate for DNA and histone demethylases (TET enzymes, JmjC-domain proteins), directly influencing epigenetic marks. It inhibits mTOR signaling, activates AMPK, and enhances mitochondrial function. In the Rejuvant formulation, AKG combined with vitamins reduced biological age by an average of 8 years in 7 months.
Adults over 40 interested in longevity, individuals with low energy, those seeking bone density support, or anyone tracking biological age through epigenetic tests. Relevant for Indians with high metabolic disease burden.
Pregnant or breastfeeding women, people with severe kidney disease (affects nitrogen metabolism), children. Side effects: Generally well-tolerated. May cause mild stomach upset or nausea at high doses. Calcium-AKG form is better tolerated for bone support.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: PMID 34417889 (Rejuvant AKG epigenetic age reversal trial, 2021), PMID 34048557 (AKG extends lifespan in mice, 2021), PMID 11336001 (ABLE study protocol, 2023)
SacredBod's longer take on Alpha-Ketoglutarate Pure — context the structured blocks above don't capture.
Alpha-ketoglutarate (AKG) is one of the most scientifically compelling longevity supplements available. As a central metabolite in the Krebs cycle, it doesn’t just produce energy — it directly modulates the epigenetic marks that determine biological age.
The groundbreaking Rejuvant trial (PMID 34417889) gave middle-aged adults a formulation containing calcium AKG plus vitamins for an average of 7 months. Results were striking: biological age measured by the TruAge DNA methylation test decreased by an average of 8 years. This was the first supplement trial to demonstrate meaningful epigenetic clock reversal in humans.
Animal studies are equally impressive. AKG supplementation extended lifespan in C. elegans worms by ~50% and in mice by ~12%. The mechanism involves inhibition of ATP synthase, activation of AMPK, and direct substrate provision to DNA/histone demethylases — enzymes that remove methyl tags from DNA, effectively ‘rejuvenating’ the epigenome.
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