Resveratrol · 3,5,4'-Trihydroxystilbene · Polygonum cuspidatum extract
250 mg · vegan · gluten-free · 60 caps
Affiliate link · we earn from qualifying purchases. No paid placements.
Trans-resveratrol is a polyphenolic stilbene found in grape skins, red wine, and Japanese knotweed (Polygonum cuspidatum). The trans isomer is the biologically active form with higher antioxidant and anti-inflammatory activity than the cis isomer.
Resveratrol activates SIRT1 (a NAD+-dependent deacetylase), AMPK, and Nrf2 pathways, potentially mimicking caloric restriction. It improves endothelial function, reduces LDL oxidation, and modulates inflammatory cytokines. However, oral bioavailability is less than 1% due to rapid intestinal and hepatic metabolism into sulfate and glucuronide conjugates. Even at 5 g doses, plasma levels of free resveratrol remain extremely low.
Adults interested in polyphenol supplementation for cardiovascular or metabolic support. Those seeking proven efficacy may prefer pterostilbene (methylated derivative with better bioavailability).
Well-tolerated up to 500 mg/day. Higher doses (2.5–5 g) may cause GI symptoms. Inhibits CYP3A4, CYP1A2, and CYP2C9—use caution with drugs metabolized by these enzymes. Avoid in pregnancy.
Pick a depth — minimum to maximal coverage
No full stack configured.
Click individual supplement pills above to buy each on Amazon India.
✓ Morning administration may have higher bioavailability due to circadian variation in metabolism
✓ Fat-containing meal improves absorption of this lipophilic polyphenol
Resveratrol activates SIRT1 (a NAD+-dependent deacetylase), AMPK, and Nrf2 pathways, potentially mimicking caloric restriction.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Elevated inflammation cohort (n≈70)
Target hsCRP <1.0 mg/L for low cardiovascular risk.
6 human volunteers
→ Oral absorption ~70%, but systemic bioavailability <1% due to rapid sulfate and glucuronide conjugation. Only trace amounts of unchanged resveratrol (<5 ng/mL) detectable in plasma after 25 mg dose
84 oral administrations across multiple trials
→ Meta-analysis of 84 administrations (25–5,000 mg) found mean Cmax of free resveratrol only 31.07 ng/mL. Linear dose-Cmax relationship but very low absolute bioavailability. Substantial heterogeneity between studies
15 healthy volunteers
→ Soluble galenic formulation of 40 mg t-Res achieved 8.8-fold higher plasma levels versus dry powder and elicited biologically efficient blood levels (0.1–6 µM) for several hours
B · Extensive preclinical promise but human bioavailability is a major obstacle. Meta-analysis confirms very low free resveratrol levels even at high doses. Some positive human trials exist (bone density, schizophrenia negative symptoms) but metabolic outcomes are often negative or mixed
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). richResearch section contains study filters.
How to use Trans-Resveratrol specifically for Cardiovascular risk — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Trans-Resveratrol — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Trans-Resveratrol — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Trans-Resveratrol — context the structured blocks above don't capture.
Trans-resveratrol is a polyphenolic stilbene found in grape skins, red wine, and Japanese knotweed (Polygonum cuspidatum). The trans isomer is the biologically active form with higher antioxidant and anti-inflammatory activity than the cis isomer.
Resveratrol activates SIRT1 (a NAD+-dependent deacetylase), AMPK, and Nrf2 pathways, potentially mimicking caloric restriction. It improves endothelial function, reduces LDL oxidation, and modulates inflammatory cytokines. However, oral bioavailability is less than 1% due to rapid intestinal and hepatic metabolism into sulfate and glucuronide conjugates. Even at 5 g doses, plasma levels of free resveratrol remain extremely low.
Who benefits most
Adults interested in polyphenol supplementation for cardiovascular or metabolic support. Those seeking proven efficacy may prefer pterostilbene (methylated derivative with better bioavailability).
Dosage and form
250 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
Mild GI upset at high doses. Mild blood-thinning effect. Avoid if you: Well-tolerated up to 500 mg/day. Higher doses (2.5–5 g) may cause GI symptoms. Inhibits CYP3A4, CYP1A2, and CYP2C9—use caution with drugs metabolized by these enzymes. Avoid in pregnancy..
The evidence
Human clinical trials and mechanistic research support the use of Trans-Resveratrol for its primary indication. See the Research tab for full citations and study summaries.
Peptides are physician-only. Tell us a bit and we'll route you to the right specialist.
