100 mg · vegan · gluten-free · 60 caps
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Pterostilbene (trans-3,5-dimethoxy-4′-hydroxystilbene) is a natural polyphenol and dimethyl ether analogue of resveratrol found in blueberries, grapes and peanuts. Its two methoxy groups make it more lipophilic than resveratrol, giving it significantly higher oral bioavailability (~80% vs ~20% in rats) and longer half-life. It crosses the blood-brain barrier and has been investigated for neuroprotective, antioxidant and longevity-promoting effects.
Pterostilbene activates the Nrf2 antioxidant pathway, upregulating heme oxygenase-1 (HO-1), superoxide dismutase (SOD) and other cytoprotective genes. It reduces oxidative stress and neuronal apoptosis in models of amyloid-β toxicity and cerebral ischemia. It also inhibits histone deacetylases (HDACs) and promotes BDNF/CREB signalling, which supports synaptic plasticity and cognitive recovery after brain injury.
Individuals seeking a more bioavailable alternative to resveratrol for antioxidant and cognitive support. Those interested in longevity science and neuroprotection. People with metabolic concerns (insulin resistance, dyslipidaemia) may also benefit from its AMPK-activating and lipid-modulating properties.
Pregnant and breastfeeding women. Individuals taking CYP2C8 substrates (e.g., pioglitazone, paclitaxel) or UGT1A6 substrates without medical guidance. Those with bleeding disorders (theoretical antiplatelet activity at high doses). Side effects: Generally well-tolerated up to 250 mg/day in human studies. Mild gastrointestinal upset at higher doses. May inhibit CYP2C8 and UGT1A6 in vitro — clinical relevance uncertain but caution advised with substrates of these enzymes.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: PMID 33280250 (Aβ-induced cognitive dysfunction via Nrf2), PMID 41707875 (post-stroke cognitive recovery via BDNF/CREB), PMID 21116625 (bioavailability vs resveratrol in rats), PMID 23417986 (pharmacokinetics and dose escalation), PMID 40227230 (pilot clinical study in diabetic retinopathy)
SacredBod's longer take on Pterostilbene — context the structured blocks above don't capture.
Pterostilbene (trans-3,5-dimethoxy-4′-hydroxystilbene) is a natural polyphenol and dimethyl ether analogue of resveratrol found in blueberries, grapes and peanuts. Its two methoxy groups make it more lipophilic than resveratrol, giving it significantly higher oral bioavailability (~80% vs ~20% in rats) and longer half-life. It crosses the blood-brain barrier and has been investigated for neuroprotective, antioxidant and longevity-promoting effects.
Pterostilbene activates the Nrf2 antioxidant pathway, upregulating heme oxygenase-1 (HO-1), superoxide dismutase (SOD) and other cytoprotective genes. It reduces oxidative stress and neuronal apoptosis in models of amyloid-β toxicity and cerebral ischemia. It also inhibits histone deacetylases (HDACs) and promotes BDNF/CREB signalling, which supports synaptic plasticity and cognitive recovery after brain injury.
Individuals seeking a more bioavailable alternative to resveratrol for antioxidant and cognitive support. Those interested in longevity science and neuroprotection. People with metabolic concerns (insulin resistance, dyslipidaemia) may also benefit from its AMPK-activating and lipid-modulating properties.
Typical dose: 100 mg per day
Form: capsules (60 count)
Best time: morning
With food: with-food
Expected onset: 4–8 weeks of consistent daily use
Cycling: No cycling required. Can be taken continuously at standard doses.
Known side effects: Generally well-tolerated up to 250 mg/day in human studies. Mild gastrointestinal upset at higher doses. May inhibit CYP2C8 and UGT1A6 in vitro — clinical relevance uncertain but caution advised with substrates of these enzymes.
Who should avoid: Pregnant and breastfeeding women. Individuals taking CYP2C8 substrates (e.g., pioglitazone, paclitaxel) or UGT1A6 substrates without medical guidance. Those with bleeding disorders (theoretical antiplatelet activity at high doses).
Avoid combining with: CYP2C8 substrates (pioglitazone, paclitaxel), UGT1A6 substrates, Anticoagulants / antiplatelets (theoretical), Resveratrol supplements (redundant), Statins (theoretical interaction via CYP)
Pterostilbene is available on Amazon India with varying brand quality. When selecting a product, verify standardization claims against the evidence base cited above. Indian brand preferences include Carbamide Forte, HealthyHey, Nutrabay Pure, Pure Nutrition, Now Foods, Nutricost, Himalaya, Patanjali, Dabur, Trexgenics, Evorina, Nervana, and Life Extension. Prices vary significantly; compare cost-per-active-dose rather than capsule count alone.
Schedule status in India: Not a Schedule H drug; available as dietary supplement/herbal product.
Key citations: PMID 33280250 (Aβ-induced cognitive dysfunction via Nrf2), PMID 41707875 (post-stroke cognitive recovery via BDNF/CREB), PMID 21116625 (bioavailability vs resveratrol in rats), PMID 23417986 (pharmacokinetics and dose escalation), PMID 40227230 (pilot clinical study in diabetic retinopathy)
Evidence grade: C+ — Animal and in-vitro studies dominate; one pilot human study in diabetic retinopathy (n=see study)
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