HT · 3,4-Dihydroxyphenylethanol · Olive polyphenol
25 mg · vegan · gluten-free · 60 caps
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Hydroxytyrosol is the most potent antioxidant polyphenol in olive oil and olive leaf extract. It is a small-molecule catechol that is both water- and lipid-soluble, allowing it to protect cellular membranes and aqueous compartments alike. The European Food Safety Authority (EFSA) has approved a health claim for hydroxytyrosol protecting LDL particles from oxidative damage at doses ≥5 mg/day.
Hydroxytyrosol scavenges peroxyl radicals, chelates transition metal ions, and upregulates endogenous antioxidant enzymes (SOD, CAT, GPx). It inhibits NF-κB and MAPK signaling, reducing pro-inflammatory cytokine production. Its bioavailability is notably higher than many other polyphenols—approximately 99% is absorbed after oral administration, with metabolites detectable in plasma within 30 minutes.
Adults seeking cardiovascular antioxidant support, particularly those wanting the key active compound from olive oil without the caloric load.
No major contraindications. Very high doses may have mild hypotensive effects. Those on blood pressure medications should monitor.
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✓ Morning dosing with breakfast provides antioxidant coverage for the day
✓ Take with a fat-containing meal to mirror natural olive oil consumption
Hydroxytyrosol scavenges peroxyl radicals, chelates transition metal ions, and upregulates endogenous antioxidant enzymes (SOD, CAT, GPx).
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Dyslipidaemia cohort (n≈75)
Target LDL <100 mg/dL for cardiovascular risk reduction.
In vitro
→ Hydroxytyrosol showed the highest antioxidant activity among olive oil phenols, with an ORAC value 10× higher than green tea catechins and 2× higher than quercetin on a molar basis
Review
→ Review of hydroxytyrosol's antioxidant, anti-inflammatory, and antiplatelet effects. Noted 99% oral bioavailability and rapid appearance of metabolites in plasma and urine
EFSA panel review
→ EFSA approved health claim: 'Olive oil polyphenols contribute to the protection of blood lipids from oxidative stress' at intake of ≥5 mg hydroxytyrosol and its derivatives per day
B · EFSA-approved health claim provides regulatory validation for LDL oxidation protection. Strong in vitro antioxidant data and good bioavailability. Human outcome trials for cardiovascular endpoints are limited but promising
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). richResearch section contains study filters.
How to use Hydroxytyrosol specifically for Oxidative stress — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Hydroxytyrosol — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Hydroxytyrosol — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Hydroxytyrosol — context the structured blocks above don't capture.
Hydroxytyrosol is the most potent antioxidant polyphenol in olive oil and olive leaf extract. It is a small-molecule catechol that is both water- and lipid-soluble, allowing it to protect cellular membranes and aqueous compartments alike. The European Food Safety Authority (EFSA) has approved a health claim for hydroxytyrosol protecting LDL particles from oxidative damage at doses ≥5 mg/day.
Hydroxytyrosol scavenges peroxyl radicals, chelates transition metal ions, and upregulates endogenous antioxidant enzymes (SOD, CAT, GPx). It inhibits NF-κB and MAPK signaling, reducing pro-inflammatory cytokine production. Its bioavailability is notably higher than many other polyphenols—approximately 99% is absorbed after oral administration, with metabolites detectable in plasma within 30 minutes.
Who benefits most
Adults seeking cardiovascular antioxidant support, particularly those wanting the key active compound from olive oil without the caloric load.
Dosage and form
25 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
Generally well-tolerated as olive polyphenol. Avoid if you: No major contraindications. Very high doses may have mild hypotensive effects. Those on blood pressure medications should monitor..
The evidence
Human clinical trials and mechanistic research support the use of Hydroxytyrosol for its primary indication. See the Research tab for full citations and study summaries.
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