D-glucarate · glucaric acid calcium salt · calcium glucarate · CDG
500 mg · vegan · gluten-free · 90 caps
Affiliate link · we earn from qualifying purchases. No paid placements.
Calcium D-glucarate is the calcium salt of D-glucaric acid, a compound found naturally in oranges, grapefruits, apples, broccoli, and Brussels sprouts. It inhibits beta-glucuronidase, an enzyme that would otherwise break down glucuronide conjugates and re-release toxins and hormones into circulation.
In Phase II liver detoxification, glucuronic acid binds to toxins, hormones, and carcinogens to form glucuronide conjugates for excretion. Beta-glucuronidase in the gut can break these conjugates, re-releasing the compounds. Calcium D-glucarate inhibits beta-glucuronidase, ensuring complete excretion of conjugated substances.
Adults with estrogen-dominant conditions, individuals seeking hormone detoxification support, those with high environmental toxin exposure, people interested in liver health optimization.
Pregnant or breastfeeding women (insufficient safety data), children, individuals with severe kidney disease, those taking medications that rely on glucuronidation (consult physician).
Pick a depth — minimum to maximal coverage
No full stack configured.
Click individual supplement pills above to buy each on Amazon India.
✓ Morning for consistent detoxification support throughout the day
✓ Food improves tolerance and absorption
In Phase II liver detoxification, glucuronic acid binds to toxins, hormones, and carcinogens to form glucuronide conjugates for excretion.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
see study
→ D-glucarate inhibited mammary, colon, and liver tumorigenesis in animal models; reduced beta-glucuronidase activity
see study
→ Calcium D-glucarate significantly reduced beta-glucuronidase activity in animal tissues
see study
→ D-glucarate reduced serum cholesterol and enhanced glucuronidation capacity (N=animal study)
C · Strong animal chemoprevention data; limited human clinical trials; mechanism is well-established; human biomarker studies needed
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). richResearch section contains study filters.
How to use Calcium D-Glucarate specifically for estrogen dominance — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Calcium D-Glucarate — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Calcium D-Glucarate — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Calcium D-Glucarate — context the structured blocks above don't capture.
Calcium D-glucarate is one of the most underappreciated detoxification compounds. While milk thistle and NAC receive attention for liver support, calcium D-glucarate operates through a distinct mechanism—enhancing Phase II glucuronidation, the conjugation pathway that neutralizes hormones, toxins, and carcinogens for urinary and fecal excretion. Its natural presence in citrus fruits and cruciferous vegetables suggests evolutionary relevance, though dietary intake is typically insufficient for therapeutic effects.
The mechanistic basis is well-characterized. In the liver, glucuronic acid binds to lipophilic compounds—including estrogens, androgens, thyroid hormones, and environmental toxins—to form water-soluble glucuronide conjugates. These conjugates travel through bile to the intestine for excretion. However, intestinal bacteria produce beta-glucuronidase, an enzyme that cleaves these conjugates, re-releasing the original compounds back into circulation. This enterohepatic recirculation means toxins and hormones can cycle repeatedly. Calcium D-glucarate inhibits beta-glucuronidase, ensuring conjugated substances are excreted rather than reabsorbed.
The animal chemoprevention data is extensive. Heerdt and colleagues (1995, Carcinogenesis, PMID 7792377) demonstrated that D-glucarate and its derivatives inhibited mammary, colon, and liver tumorigenesis in multiple animal models. The mechanism involved both beta-glucuronidase inhibition and direct effects on cell proliferation. Dwivedi and colleagues (1990, Biochemical Medicine and Metabolic Biology, PMID 2318106) established that calcium D-glucarate significantly reduced beta-glucuronidase activity in animal tissues, confirming the biochemical mechanism. Hanausek and colleagues (2003, European Journal of Cancer Prevention, PMID 12616618) extended this to show cholesterol-lowering effects and enhanced glucuronidation capacity.
The human clinical trial gap is the primary limitation. While animal data is robust and the mechanism is well-established, large human trials demonstrating clinical outcomes are lacking. The compound is safe—derived from natural food sources with no significant toxicity reported—but efficacy in humans relies primarily on mechanistic extrapolation and small biomarker studies. The honest framing: calcium D-glucarate has excellent mechanistic rationale for supporting hormone detoxification, strong animal chemoprevention data, and an excellent safety profile. Its role is as a supportive adjunct for liver detoxification and estrogen metabolism, not as a standalone treatment for any condition.
Peptides are physician-only. Tell us a bit and we'll route you to the right specialist.
