What it is
L-Citrulline malate is the malic-acid salt of L-citrulline, a non-essential amino acid that converts to L-arginine in the kidneys and drives nitric oxide production. The malate portion contributes to Krebs-cycle ATP recycling.
Supplement · Amino Acid & Nitric Oxide
L-Citrulline Malate
CMA 2:1
6–8 g · vegan · gluten-free · 30 caps
reduced-exercise-capacityerectile-dysfunctionhypertensionmuscle-weakness kidneyblood vesselmuscle
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How it works
Oral citrulline avoids the hepatic arginase that degrades most ingested arginine, so plasma arginine and NO rise more than with arginine itself. NO dilates arteries, improving flow to working muscle, brain, and the genitourinary system.
Who should take it
Athletes, adults with mild hypertension, men with mild erectile dysfunction, and endurance-focused training. Useful in Indian heat where vasodilation can offset training-load fatigue.
Avoid / careful
Anyone on PDE5 inhibitors or strong nitrates. Caution with severe kidney disease.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
Why is L-Citrulline Malate better than L-Arginine?
L-Citrulline Malate bypasses the liver's first-pass metabolism and arginase enzyme, leading to higher and more sustained increases in plasma L-arginine and nitric oxide compared to taking L-arginine directly.
Can L-Citrulline Malate help with erectile dysfunction?
Yes, by increasing nitric oxide, L-Citrulline Malate promotes vasodilation, which can improve blood flow to the penis, potentially alleviating symptoms of mild erectile dysfunction.
Is L-Citrulline Malate safe for everyone?
It is generally safe, but individuals on specific medications like PDE5 inhibitors or nitrates, and those with severe kidney issues, should exercise caution or consult a healthcare professional.
Research summary
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
RCTs show improved time-to-exhaustion in trained males and modest blood-pressure benefits. Meta-analyses converge on endurance and vasodilation effects at 6+ g doses.
From the blog
Editorial notes
SacredBod's longer take on L-Citrulline Malate — context the structured blocks above don't capture.
L-Citrulline Malate is a amino acid & nitric oxide supplement. L-Citrulline malate is the malic-acid salt of L-citrulline, a non-essential amino acid that converts to L-arginine in the kidneys and drives nitric oxide production. The malate portion contributes to Krebs-cycle ATP recycling.
How it works
Oral citrulline avoids the hepatic arginase that degrades most ingested arginine, so plasma arginine and NO rise more than with arginine itself. NO dilates arteries, improving flow to working muscle, brain, and the genitourinary system.
Who it’s for
Athletes, adults with mild hypertension, men with mild erectile dysfunction, and endurance-focused training. Useful in Indian heat where vasodilation can offset training-load fatigue.
Dosage & timing
- Typical dose: 6–8 g
- Best time: morning
- With food: before-food
- Expected onset: Acute pump within 60–90 min; chronic effects at 2–4 weeks.
India context
Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.
Safety
Anyone on PDE5 inhibitors or strong nitrates. Caution with severe kidney disease.
Added to your stack.