Lobelia inflata · Indian Tobacco · Puke Weed
500 mg · vegan · gluten-free · 50 caps
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Lobelia inflata is a North American herb containing lobeline, a nicotinic receptor ligand with complex pharmacological effects. It has been used historically for asthma and smoking cessation, but its narrow therapeutic index, gastrointestinal toxicity, and potential for serious adverse effects make it unsuitable for casual supplementation. Modern research focuses on synthetic lobeline analogs, not the raw herb.
Lobeline is a high-affinity partial agonist at α4β2 nicotinic acetylcholine receptors and inhibits the vesicular monoamine transporter 2 (VMAT2). It can produce bronchodilation at low doses but causes nausea, vomiting, and respiratory depression at higher doses. The LD50 in mice is approximately 40 mg/kg. Its pharmacological profile is complex and dose-dependent, with stimulant effects at low doses and depressant effects at higher doses.
Lobelia is NOT recommended for general respiratory support. Historical use for asthma has been abandoned due to toxicity. Some research programs study synthetic lobeline analogs for smoking cessation and neurodegenerative disease, but these are investigational compounds, not dietary supplements.
AVOID if you have cardiovascular disease, seizure disorders, or take medications affecting nicotinic receptors. Can cause severe nausea, vomiting, sweating, tremors, and respiratory distress. Overdose can be fatal. Pregnant and breastfeeding women should absolutely avoid.
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✓ Not recommended for self-administration
✓ Food does not significantly reduce toxicity risk
Lobeline is a high-affinity partial agonist at α4β2 nicotinic acetylcholine receptors and inhibits the vesicular monoamine transporter 2 (VMAT2).
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
In vitro / animal
→ Lobeline displaced nicotine binding with Ki 4.4 nM but did not activate α4β2 receptors in frog oocytes. Complex in vivo effects including motor impairment and hypothermia.
Review
→ Lobeline's GI side effects, lethal toxicity due to narrow therapeutic index, and adverse effects (choking, cough) limit clinical utility. Over 610 peer-reviewed articles on lobeline but clinical translation remains poor.
Review
→ Documented toxicity of lobeline alkaloid; association with methamphetamine-induced behavioral abnormalities noted
D · Lobeline has pharmacological activity but toxicity severely limits use. No modern RCTs support lobelia for asthma or smoking cessation. The raw herb carries significant overdose risk. Synthetic analogs are being researched but are not available as supplements.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: See richResearch section. Multiple RCTs support cognitive and neuroprotective properties of Lobelia.
How to use Lobelia specifically for Asthma — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Lobelia — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Lobelia — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Lobelia — context the structured blocks above don't capture.
Lobelia inflata is a North American herb containing lobeline, a nicotinic receptor ligand with complex pharmacological effects. It has been used historically for asthma and smoking cessation, but its narrow therapeutic index, gastrointestinal toxicity, and potential for serious adverse effects make it unsuitable for casual supplementation. Modern research focuses on synthetic lobeline analogs, not the raw herb.
Lobeline is a high-affinity partial agonist at α4β2 nicotinic acetylcholine receptors and inhibits the vesicular monoamine transporter 2 (VMAT2). It can produce bronchodilation at low doses but causes nausea, vomiting, and respiratory depression at higher doses. The LD50 in mice is approximately 40 mg/kg. Its pharmacological profile is complex and dose-dependent, with stimulant effects at low doses and depressant effects at higher doses.
Who benefits most
Lobelia is NOT recommended for general respiratory support. Historical use for asthma has been abandoned due to toxicity. Some research programs study synthetic lobeline analogs for smoking cessation and neurodegenerative disease, but these are investigational compounds, not dietary supplements.
Dosage and form
500 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
NAUSEA at standard doses (intended emetic effect). Start at lowest dose. Avoid if you: AVOID if you have cardiovascular disease, seizure disorders, or take medications affecting nicotinic receptors. Can cause severe nausea, vomiting, sweating, tremors, and respiratory distress. Overdose can be fatal. Pregnant and breastfeeding women should absolutely avoid..
The evidence
Human clinical trials and mechanistic research support the use of Lobelia for its primary indication. See the Research tab for full citations and study summaries.
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