What it is
Methylene blue is a centuries-old pharmaceutical dye repurposed at low doses as a mitochondrial cofactor. The blue colour is visible.
Supplement · Longevity & Mitochondrial
Methylene Blue (Low Dose)
MB, methylthioninium chloride
0.5–2 mg/kg (low dose: 5–25 mg) · vegan · gluten-free · 30 caps
muscle-fatiguememory-lossbrain-fog brainmitochondrialiver
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How it works
MB acts as an alternative electron acceptor at complex IV of the electron transport chain, bypassing damaged sections and supporting ATP generation.
Who should take it
Adults with mitochondrial fatigue phenotypes, midlife cognitive decline concerns, brain fog. Use pharmaceutical-grade only.
Avoid / careful
Anyone on SSRIs/SNRIs — serotonin syndrome risk. G6PD deficiency. Watch for green/blue urine.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
Flexible — works in any of the above.
FAQs
Frequently asked
Can I use any methylene blue?
No, only pharmaceutical-grade methylene blue is recommended for internal use to ensure purity and absence of contaminants.
What are the risks of taking methylene blue with antidepressants?
Methylene blue can inhibit monoamine oxidase (MAO) and interact with SSRIs/SNRIs, potentially leading to a life-threatening serotonin syndrome. Consult your doctor before use.
Will methylene blue turn my urine blue?
Yes, a common side effect of methylene blue is the temporary discoloration of urine to green or blue. This is generally harmless.
Research summary
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Small human cognitive RCTs show acute working-memory improvements; long-term safety data is limited at low doses.
From the blog
Editorial notes
SacredBod's longer take on Methylene Blue (Low Dose) — context the structured blocks above don't capture.
Methylene Blue (Low Dose) is a longevity & mitochondrial supplement. Methylene blue is a centuries-old pharmaceutical dye repurposed at low doses as a mitochondrial cofactor. The blue colour is visible.
How it works
MB acts as an alternative electron acceptor at complex IV of the electron transport chain, bypassing damaged sections and supporting ATP generation.
Who it’s for
Adults with mitochondrial fatigue phenotypes, midlife cognitive decline concerns, brain fog. Use pharmaceutical-grade only.
Dosage & timing
- Typical dose: 0.5–2 mg/kg (low dose: 5–25 mg)
- Best time: morning
- With food: flexible
- Expected onset: Acute cognitive effects within 60 min.
- Cycling: 5 days on, 2 days off recommended.
India context
Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.
Safety
Anyone on SSRIs/SNRIs — serotonin syndrome risk. G6PD deficiency. Watch for green/blue urine.
Added to your stack.