Vinca minor extract · Cavinton · Ethyl apovincaminate
10 mg · vegan · gluten-free · 60 caps
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Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine, extracted from the periwinkle plant (Vinca minor). It is widely used in Europe and Asia for cerebrovascular disorders and is available as a dietary supplement in India.
Vinpocetine inhibits phosphodiesterase-1 (PDE1), increasing cGMP and producing cerebral vasodilation. It also suppresses NF-κB and NLRP3 inflammasome activation in retinal pigment epithelium, reducing pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in AMD models. Direct human retinal circulation data is limited.
Adults seeking vascular support for cognitive or eye health where legal. Not a first-line eye supplement—consider only after foundational nutrients (lutein, DHA, zinc).
Banned or restricted in Australia, Canada, and some EU countries. Legal in India as a supplement. Avoid in pregnancy and lactation. Use caution with anticoagulants.
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✓ Morning and midday dosing preferred; may cause mild alertness
✓ Morning and midday dosing preferred; may cause mild alertness
✓ Take with meals to improve absorption and reduce GI discomfort
Vinpocetine inhibits phosphodiesterase-1 (PDE1), increasing cGMP and producing cerebral vasodilation.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
Pilot study
→ 12-week oral vinpocetine therapy significantly increased cerebral blood flow velocity at rest and after breath-holding, with parallel cognitive improvement
Ex vivo rat retina
→ Vinpocetine decreased unregulated cation entry into ischemic ganglion cells and prevented loss of calretinin/parvalbumin immunoreactivity
13 patients (PET study)
→ 14-day IV vinpocetine redistributed cerebral blood flow toward thalamus and caudate nucleus, with regional glucose metabolism changes
B · Strong preclinical and small clinical data for cerebral blood flow; retinal anti-inflammatory mechanisms are validated in RPE models but human ocular trials are absent
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: PMID 14664718 (Szilágyi 2005, cerebral blood flow study), PMID 15845575 (Feigin 2001, Cochrane stroke review), PMID 17622826 (DeAngelis 2015, neuroprotection review).
How to use Vinpocetine specifically for Poor circulation — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Vinpocetine — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Vinpocetine — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Vinpocetine — context the structured blocks above don't capture.
Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine, extracted from the periwinkle plant (Vinca minor). It is widely used in Europe and Asia for cerebrovascular disorders and is available as a dietary supplement in India.
Vinpocetine inhibits phosphodiesterase-1 (PDE1), increasing cGMP and producing cerebral vasodilation. It also suppresses NF-κB and NLRP3 inflammasome activation in retinal pigment epithelium, reducing pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in AMD models. Direct human retinal circulation data is limited.
Who benefits most
Adults seeking vascular support for cognitive or eye health where legal. Not a first-line eye supplement—consider only after foundational nutrients (lutein, DHA, zinc).
Dosage and form
10 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
Headache, mild GI. Blood pressure changes possible. Avoid if you: Banned or restricted in Australia, Canada, and some EU countries. Legal in India as a supplement. Avoid in pregnancy and lactation. Use caution with anticoagulants..
The evidence
Human clinical trials and mechanistic research support the use of Vinpocetine for its primary indication. See the Research tab for full citations and study summaries.
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