What it is
Zinc-L-carnosine (polaprezinc) is a 1:1 chelate of zinc and L-carnosine, available in Japan as a prescription mucosal protectant since the 1990s.
Supplement · Gut Health & Mucosal
Zinc-L-Carnosine
Polaprezinc
75 mg twice daily · vegan · gluten-free · 60 caps
peptic-ulcerindigestion stomachskin
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How it works
The chelate adheres preferentially to ulcer surfaces, releasing zinc and carnosine in-situ. Carnosine reduces local inflammation and zinc supports epithelial repair.
Who should take it
Adults with active peptic ulcer (with PPI), functional dyspepsia, GERD, or NSAID-induced gastritis.
Avoid / careful
Coordinate with PPI or H2 blocker therapy. Watch zinc accumulation at high doses.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
FAQs
Frequently asked
How does zinc-L-carnosine differ from standard zinc supplements?
Zinc-L-carnosine is a chelated compound designed to bind to damaged mucosal tissue, providing targeted delivery of zinc and carnosine directly to the site of injury.
Can I take zinc-L-carnosine with my antacid medication?
It is generally recommended to coordinate its use with PPIs or H2 blockers. Consult your healthcare provider for specific advice regarding antacid use.
What is the typical duration of use for zinc-L-carnosine?
Duration of use often depends on the severity of the condition and physician recommendation. Follow your doctor's guidance for optimal treatment.
Research summary
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Japanese RCTs (Mahmood et al.) at 150 mg/day show H. pylori adjunct benefit and accelerated ulcer healing.
From the blog
Editorial notes
SacredBod's longer take on Zinc-L-Carnosine — context the structured blocks above don't capture.
Zinc-L-Carnosine is a gut health & mucosal supplement. Zinc-L-carnosine (polaprezinc) is a 1:1 chelate of zinc and L-carnosine, available in Japan as a prescription mucosal protectant since the 1990s.
How it works
The chelate adheres preferentially to ulcer surfaces, releasing zinc and carnosine in-situ. Carnosine reduces local inflammation and zinc supports epithelial repair.
Who it’s for
Adults with active peptic ulcer (with PPI), functional dyspepsia, GERD, or NSAID-induced gastritis.
Dosage & timing
- Typical dose: 75 mg twice daily
- Best time: morning
- With food: between-meals
- Expected onset: 2–4 weeks for ulcer healing.
India context
Availability on Amazon India is currently limited or import-only for this form. International brands (iHerb, NOW Foods, Doctor’s Best) ship to India with variable customs handling. Local Ayurvedic equivalents may offer overlapping benefits.
Safety
Coordinate with PPI or H2 blocker therapy. Watch zinc accumulation at high doses.
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