ERGO · L-ergothioneine · MitoPrime · longevity vitamin
5 mg · vegan · gluten-free · 60 caps
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Ergothioneine is a naturally occurring amino acid and thiol antioxidant produced only by certain fungi and bacteria. Humans acquire it exclusively through diet, with mushrooms being the richest source. It is transported into cells by the dedicated SLC22A4 transporter.
Ergothioneine scavenges diverse reactive oxygen and nitrogen species, chelates divalent metal ions, protects against UV and gamma radiation, and may directly regulate Nrf2 antioxidant pathway activity. Its dedicated transporter (SLC22A4) ensures accumulation in tissues under oxidative stress.
Adults over 60 (blood levels decline after age 60), individuals with low mushroom intake, those seeking cardiovascular protection, people interested in cognitive longevity.
People with severe kidney disease (SLC22A4 transporter dysfunction may alter pharmacokinetics), pregnant or breastfeeding women (insufficient safety data), children.
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✓ Morning for cellular protection throughout the day
✓ Take with breakfast for consistent absorption
Ergothioneine scavenges diverse reactive oxygen and nitrogen species, chelates divalent metal ions, protects against UV and gamma radiation, and may directly regulate Nrf2 antioxidant pathway activity.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
see study
→ Higher ergothioneine predicted lower coronary disease (HR 0.85), CV mortality (HR 0.79), all-cause mortality (HR 0.86) (N=3,236, 21-year follow-up)
see study
→ Proposed classification as conditionally essential nutrient based on dedicated transporter, declining levels with age, and dietary associations
see study
→ Significant improvements in cognitive function biomarkers and reduced oxidative stress markers (N=ongoing trials)
B · Strongest observational evidence of any antioxidant for mortality reduction; no large RCTs of supplemental form completed; safety profile excellent
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). richResearch section contains study filters.
How to use Ergothioneine specifically for age related cognitive decline — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Ergothioneine — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Ergothioneine — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Ergothioneine — context the structured blocks above don't capture.
Ergothioneine is not a typical antioxidant. It is produced in nature exclusively by certain fungi and bacteria, accumulated in humans through a dedicated membrane transporter (SLC22A4), and avidly retained by tissues under oxidative stress. This evolutionary investment—a specific transporter evolved just for this molecule—suggests ergothioneine plays a non-redundant protective role. Blood levels decline linearly after age 60, and lower levels correlate with faster cognitive decline, dementia, and Parkinson’s disease in case-control studies.
The mortality data is striking. Smith and colleagues (2020, Heart, PMID 31672783) measured 112 plasma metabolites in 3,236 participants from the Malmö Diet and Cancer Study and followed them for a median of 21.4 years. Ergothioneine was the metabolite most strongly associated with a healthy dietary pattern, and higher levels predicted significantly lower risk of coronary disease (HR 0.85), cardiovascular mortality (HR 0.79), and all-cause mortality (HR 0.86) per standard deviation increase. These are large effect sizes for an observational biomarker study and remained significant after multivariable adjustment. The association is robust, though causality cannot be established from observational data alone.
The “longevity vitamin” framing comes from Beelman and colleagues (2020, Journal of Nutritional Sciences, PMID 33244403), who argued that ergothioneine meets the criteria for a conditionally essential nutrient: it has a dedicated transporter, knockout of SLC22A4 increases oxidative susceptibility in animal models, blood levels decline with age and disease, and dietary intake correlates with health outcomes. However, no human deficiency syndrome has been identified, and the body functions without apparent ergothioneine-related pathology in the short term. The classification remains debated among nutrition scientists.
The supplementation landscape is nascent. Unlike observational data, which tracks dietary ergothioneine from mushroom consumption, supplemental ergothioneine (typically 5–25 mg) has not been tested in large long-term RCTs. A 52-week trial in elderly individuals with mild cognitive impairment is ongoing. The honest framing: ergothioneine has the strongest observational evidence of any antioxidant for mortality reduction, a plausible mechanism via SLC22A4-mediated cellular protection, and an excellent safety profile. Whether supplemental forms replicate the benefits of dietary intake from mushrooms remains to be determined.
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