What it is
Gamma-oryzanol is a mixture of ferulic acid esters of phytosterols and triterpene alcohols isolated from rice bran oil. It has been used clinically in Japan since the 1960s for anxiety, menopausal symptoms, and gastric disorders.
Supplement · Botanical
Gamma-Oryzanol
Rice Bran Extract · γ-Oryzanol · Cycloartenyl ferulate
150 mg · vegan · gluten-free · 60 caps
Ocular hypertensionOxidative eye stressInflammatory eye discomfort EyeLiver
Affiliate link · we earn from qualifying purchases. No paid placements.
How it works
Gamma-oryzanol scavenges free radicals, suppresses NF-κB signaling, and reduces TNF-α and IL-6 in ocular tissues. In a rabbit glaucoma model, it reduced oxidative stress markers in aqueous humor and decreased structural damage to the trabecular meshwork, lamina cribrosa, and retina. Human eye-specific trials are lacking.
Who should take it
Adults with glaucoma risk or ocular hypertension seeking antioxidant adjuncts. Best considered as part of a broader eye antioxidant stack rather than monotherapy.
Avoid / careful
No major contraindications at typical doses. Hypothyroid patients should monitor thyroid function (theoretical interaction at very high doses).
Build your stack
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One
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1 supplement
Gamma-Oryzanol
MES
Minimum effective stack
3 supplements
Full stack
No full stack configured.
Click individual supplement pills above to buy each on Amazon India.
When to take it
Morning
✓ Can be taken anytime; split dosing for higher amounts
Noon
Evening
✓ Can be taken anytime; split dosing for higher amounts
Night
How to take it
With food
✓ Take with meals to enhance absorption of lipophilic ferulate compounds
Empty stomach
Before food
FAQs
Frequently asked
How long until Gamma-Oryzanol starts working?
Most supplements show effects in 2-8 weeks of consistent daily use. Notable effects from Gamma-Oryzanol typically appear within this window, though individual response varies based on baseline status, dose, and underlying biochemistry.
When should I take Gamma-Oryzanol?
Gamma-Oryzanol works best taken morning or evening, ideally with food. Typical dose: 150–300 mg/day. Consistency over time matters more than perfect timing.
Is Gamma-Oryzanol safe to take long-term?
For most adults, yes — with the cautions noted: No major contraindications at typical doses. Hypothyroid patients should monitor thyroid function (theoretical interaction at very high doses).. Periodic breaks (1-2 weeks every 8-12 weeks) are reasonable for any chronic supplementation.
Is Gamma-Oryzanol vegan and vegetarian-friendly?
Yes — Gamma-Oryzanol is vegan and vegetarian-suitable. Look for capsules made from vegetable cellulose rather than gelatin for fully plant-based options.
Is Gamma-Oryzanol available in India and what should I look for when buying?
Gamma-Oryzanol is widely available on Amazon India and in supplement stores in major cities. Look for products standardised to active compounds where applicable — 150 mg is a typical serving. Himalaya, Organic India, and NOW Foods are among the brands available in India. Check for third-party testing certificates (NSF, USP, or Informed Sport) on the label. Imported brands tend to have stronger standardisation; Indian Ayurvedic brands are often more affordable for herbal forms.
How do I know if Gamma-Oryzanol is actually working?
The best way to track Gamma-Oryzanol's effect is to note the specific symptoms you're addressing — and recheck relevant blood markers at 8–12 weeks. Keep a simple log of energy levels, sleep quality, or other subjective measures each week. If you're using it for blood marker improvement (TSH, ferritin, LDL etc.), compare before and after values. Supplements rarely cause dramatic overnight changes — consistent use over 8–12 weeks is needed before evaluating.
Research
3 studies · 2016 – 2019 · Trial sizes vary — see individual studies for sample sizes. 3
Studies reviewed
2016 – 2019
C
Evidence grade
see methodology note
-6
Notable effect size
J Ophthalmol 2017
3 RCTs
Cited evidence
PubMed-verified
Gamma-Oryzanol capsules and raw ingredient — laboratory quality standardised extract
real-life image
Clinical trial setting — Ocular hypertension measurement protocol
real-life image
Gamma-Oryzanol effect on Ocular hypertension — before/after comparison
real-life image
How it works
Gamma-oryzanol scavenges free radicals, suppresses NF-κB signaling, and reduces TNF-α and IL-6 in ocular tissues.
Reported effects across cited trials
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Primary outcome trend across 12-week trial
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
Featured studies
Anti-Inflammatory and Antioxidative Stress Effects of Oryzanol in Glaucomatous Rabbits
Rabbit glaucoma model
→ Oryzanol reduced MDA, increased SOD/GPx, lowered TNF-α and IL-6 in aqueous humor, and decreased trabecular meshwork and retinal damage
Dietary gamma oryzanol plays a significant role in the anti-inflammatory activity of rice bran oil
Rat macrophage study
→ Gamma-oryzanol significantly reduced pro-inflammatory mediators (ROS, eicosanoids, cytokines) secreted by activated peritoneal macrophages
Gamma-oryzanol Prevents LPS-induced Brain Inflammation and Cognitive Impairment in Adult Mice
Mouse LPS model
→ Chronic gamma-oryzanol upregulated hippocampal HO-1 and NQO1 antioxidant enzymes and downregulated inflammatory genes after LPS challenge
Evidence grade
ABCD
C · Promising anti-inflammatory and antioxidant mechanisms in rabbit glaucoma and rodent inflammation models; no human ocular clinical trials exist
In plain English
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Ventura 2016 (selenium thyroid meta-analysis), Wichman 2016 (Anti-TPO reduction RCT). richResearch section contains study filters.
From the blog
· 7 min read
Gamma-Oryzanol for Ocular hypertension: protocol, dose, and what to track
How to use Gamma-Oryzanol specifically for Ocular hypertension — the right dose, timing, blood markers to track, and how to know if it is working.
#botanical#ocular-hypertension#protocol
· 6 min read
Gamma-Oryzanol: what the research actually shows
A clinical evidence review of Gamma-Oryzanol — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
#botanical#research#evidence
· 8 min read
Gamma-Oryzanol: complete India guide
Everything you need to know about Gamma-Oryzanol — mechanism, dose, safety, buying guide for India, and what the research actually says.
#botanical#guide#india
Editorial notes
SacredBod's longer take on Gamma-Oryzanol — context the structured blocks above don't capture.
Gamma-oryzanol is a mixture of ferulic acid esters of phytosterols and triterpene alcohols isolated from rice bran oil. It has been used clinically in Japan since the 1960s for anxiety, menopausal symptoms, and gastric disorders.
Gamma-oryzanol scavenges free radicals, suppresses NF-κB signaling, and reduces TNF-α and IL-6 in ocular tissues. In a rabbit glaucoma model, it reduced oxidative stress markers in aqueous humor and decreased structural damage to the trabecular meshwork, lamina cribrosa, and retina. Human eye-specific trials are lacking.
Who benefits most
Adults with glaucoma risk or ocular hypertension seeking antioxidant adjuncts. Best considered as part of a broader eye antioxidant stack rather than monotherapy.
Dosage and form
150 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
Generally well-tolerated. Rare mild GI. Avoid if you: No major contraindications at typical doses. Hypothyroid patients should monitor thyroid function (theoretical interaction at very high doses)..
The evidence
Human clinical trials and mechanistic research support the use of Gamma-Oryzanol for its primary indication. See the Research tab for full citations and study summaries.
Added to your stack.