EGCG · Epigallocatechin Gallate · Green Tea Catechins
200–400 mg EGCG · vegan · gluten-free · 180 caps
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Green tea extract (GTE) is a concentrated preparation of polyphenols—primarily epigallocatechin gallate (EGCG)—from *Camellia sinensis* leaves. A single capsule of a standardized extract can deliver the catechin equivalent of 2–3 cups of brewed green tea. Unlike drinking green tea, supplements provide a bolus dose that bypasses the gradual absorption and dilution of an infusion, altering the safety profile.
EGCG scavenges free radicals, inhibits catechol-O-methyltransferase (COMT), and modulates cell-signaling pathways involved in inflammation and lipid metabolism. At low-to-moderate doses these effects may support vascular and metabolic health. At high bolus doses (>800 mg EGCG/day), EGCG overwhelms hepatic conjugation pathways, generating reactive metabolites that can injure hepatocytes—an effect confirmed in multiple intervention trials.
Adults seeking antioxidant support or metabolic adjuncts who have no liver disease and are not taking hepatotoxic medications. Not recommended for people using green tea extracts for "fat burning" without medical supervision.
Avoid if you have liver disease, elevated baseline transaminases, or take medications metabolized by the liver (statins, paracetamol, warfarin). Pregnant and breastfeeding women should avoid concentrated extracts; brewed tea in moderation is generally considered safe. Discontinue immediately if you notice dark urine, jaundice, or right-upper-quadrant pain.
✓ Morning is preferred to avoid sleep disruption from residual caffeine in non-decaffeinated extracts.
✓ Always take with food; fasting increases hepatotoxicity risk in animal models.
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Each bar = one cited trial. Effect varies by methodology, dose, and population.
Elevated liver enzymes cohort (n≈68)
Target ALT <40 U/L (upper limit of normal).
see study
→ No consistent evidence that green tea extracts reduce cardiovascular events; modest LDL reduction in some trials.
see study
→ Doses ≥800 mg EGCG/day from supplements cause statistically significant elevations of ALT/AST in a subset of users.
see study
→ UGT1A4 A/C genotype carriers showed ~80% ALT elevation at 6–9 months on 843 mg/day EGCG; genetic risk factor confirmed.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). richResearch section contains study filters.
How to use Green Tea Extract specifically for oxidative stress — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Green Tea Extract — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Green Tea Extract — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Green Tea Extract — context the structured blocks above don't capture.
Drinking green tea is safe for almost everyone and may offer modest cardiovascular and metabolic benefits. Concentrated green tea extract is a different product with a different risk profile. The EFSA 2018 safety review concluded that supplements delivering ≥800 mg EGCG/day cause elevated liver enzymes in a small percentage of users—usually less than 10%, but with serious consequences for those affected. France has banned some high-dose GTE weight-loss products. The “fat burning” marketing massively outruns the RCT data: no large trial has shown meaningful weight loss from GTE that justifies the hepatotoxicity risk. If you choose to use GTE, stay well below 800 mg EGCG/day, take it with food, and avoid stacking with other liver-stressing compounds.
Take 1 capsule (200–400 mg EGCG) with breakfast. Do not take on an empty stomach. Cycle off after 12 weeks for 2–4 weeks to reduce cumulative hepatic exposure.
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