Supplement · Adaptogen & Longevity

Jiaogulan (Gynostemma, High Gypenosides)

Gynostemma pentaphyllum

450 mg standardised · vegan · gluten-free · 60 caps

metabolic-syndromeoxidative stressanxiety liverpancreasadrenal gland

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What it is

Jiaogulan (Gynostemma, High Gypenosides) is a adaptogen & longevity supplement. High-gypenoside jiaogulan (Gynostemma pentaphyllum), the 'herb of immortality', is an adaptogen with ginseng-like saponins. Used in adult dosing protocols in India and internationally, it is sold as a single-ingredient supplement.

How it works

Gypenosides activate AMPK to improve metabolic and lipid handling, support antioxidant defence and modulate the stress response and nitric oxide, underpinning its longevity reputation. Effects are dose-dependent and typically measurable within 2-6 weeks.

Who should take it

Adults seeking metabolic, adaptogenic and healthy-ageing support.

Avoid / careful

Mildly hypoglycaemic and antiplatelet — caution with relevant medication. Generally well tolerated.

When to take it

Morning

Noon

Evening

Night

How to take it

With food

Empty stomach

Before food

FAQs

Frequently asked

How does Jiaogulan compare to Ginseng?

Both are adaptogens with saponins, but Jiaogulan's gypenosides are structurally different from Ginseng's ginsenosides, leading to distinct, though sometimes overlapping, benefits, particularly in AMPK activation.

What is AMPK and why is it important?

AMPK (AMP-activated protein kinase) is an enzyme that acts as a cellular energy sensor. Activating AMPK can improve glucose uptake, fatty acid oxidation, and mitochondrial biogenesis, supporting metabolic health and longevity.

Can Jiaogulan help with stress?

Yes, Jiaogulan is an adaptogen that helps the body modulate its response to stress, potentially improving resilience and reducing the negative impact of chronic stress.