Citrus bergamia · bergamot orange · bergamotto · Citrus aurantium var. bergamia
500 mg · vegan · gluten-free · 90 caps
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Bergamot is a citrus fruit grown primarily in the Calabria region of Italy. Its extract is rich in unique polyphenols including neoeriocitrin, naringin, and neohesperidin, which have been shown to influence lipid metabolism and vascular health.
Bergamot polyphenols inhibit HMG-CoA reductase (similar to statins but less potently), activate AMPK to improve glucose uptake, and enhance HDL functionality. They also exhibit anti-inflammatory and antioxidant effects in vascular endothelium.
Adults with mild-to-moderate cholesterol elevation, individuals with metabolic syndrome, those seeking vascular support, people interested in Mediterranean-derived supplements.
People taking prescription statins (potential additive effect), those with severe liver disease, pregnant or breastfeeding women, children, individuals with citrus allergies.
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✓ Morning for metabolic activation throughout the day
✓ Food improves polyphenol absorption and reduces GI discomfort
Bergamot polyphenols inhibit HMG-CoA reductase (similar to statins but less potently), activate AMPK to improve glucose uptake, and enhance HDL functionality.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Dyslipidaemia cohort (n≈75)
Target LDL <100 mg/dL for cardiovascular risk reduction.
see study
→ BPF 1,000 mg/day reduced LDL by 38%, increased HDL by 43% over 30 days (N=77, open-label)
see study
→ Bergamot extract reduced cholesterol by 42%, LDL by 38%, glucose by 22% in metabolic syndrome (N=237)
see study
→ Meta-analysis: significant reductions in total cholesterol, LDL, and triglycerides; HDL increase (N=multiple trials)
B · Promising lipid and glycemic data; many trials are open-label or from single research group; independent replication needed
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). richResearch section contains study filters.
How to use Bergamot specifically for high cholesterol — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Bergamot — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Bergamot — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Bergamot — context the structured blocks above don't capture.
Bergamot has emerged from relative obscurity to become one of the most studied citrus-derived supplements for metabolic health. Unlike common citrus fruits, bergamot (Citrus bergamia) grown in Calabria, Italy contains a unique profile of polyphenols—neoeriocitrin, naringin, neohesperidin, and brutieridin—that appear to influence lipid metabolism through multiple mechanisms. The research base is growing but concentrated, with much of the clinical work originating from Italian research groups.
The lipid data is genuinely promising. Mollace and colleagues (2011, Fitoterapia, PMID 21199736) conducted an open-label study in 237 patients with metabolic syndrome, testing bergamot extract at 500–1,000 mg daily for 30 days. Total cholesterol fell by approximately 42%, LDL by 38%, and fasting glucose by 22%. These are large effect sizes, though the open-label design without placebo control limits confidence. Gliozzi and colleagues (2013, Advances in Biological Chemistry, PMID 23996187) refined this work, showing that bergamot polyphenolic fraction (BPF) at 1,000 mg daily reduced LDL by 38% and increased HDL by 43% over 30 days in 77 patients. The HDL elevation is particularly notable—most lipid-lowering interventions raise HDL only modestly.
The mechanism is distinct from statins. While bergamot polyphenols do inhibit HMG-CoA reductase, they are far less potent than statins and appear to work primarily through AMPK activation and PCSK9 modulation. This may explain why side effect profiles are milder than pharmaceutical statins. However, the honest framing requires acknowledging that much of the clinical evidence comes from a single research group (Mollace et al. at the University of Catanzaro), and independent replication from other centers is limited. The 2016 meta-analysis by Toth and colleagues (Integrative Medicine, PMID 26745699) pooled available trials and confirmed significant reductions in total cholesterol, LDL, and triglycerides, but noted heterogeneity in study designs.
The glycemic effects add another dimension. Bergamot polyphenols activate AMP-activated protein kinase (AMPK), improving insulin sensitivity and glucose uptake in muscle cells. This makes bergamot potentially useful in metabolic syndrome where dyslipidemia and insulin resistance coexist. The combination of lipid and glucose benefits is mechanistically plausible but requires larger, placebo-controlled trials to establish clinical significance. The honest framing: bergamot is a promising Mediterranean-derived supplement with genuine lipid-lowering activity, but the evidence base is concentrated and needs broader independent validation.
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