Daflon · MPFF · Citrus flavonoid complex
500 mg · vegan · gluten-free · 60 caps
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Combination of two citrus flavonoids — diosmin (450 mg) and hesperidin (50 mg) — typically in micronized purified flavonoid fraction (MPFF). Branded as Daflon in France; available as Detralex and other names in EU. Pharmaceutical-grade in many countries, supplement-grade in others including India.
Increases venous tone, reduces capillary permeability, and improves lymphatic drainage. Micronization (sub-2-micron particle size) dramatically improves bioavailability — non-micronized versions have weaker effects. Reduces inflammation markers in venous walls.
Adults with chronic venous insufficiency, hemorrhoid bleeding/symptoms, post-thrombotic syndrome, or lymphedema. Pregnancy hemorrhoids (often used in obstetrics in EU).
Lactation (limited data). Concurrent strong anticoagulants. Some interactions with calcium channel blockers reported.
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✓ Morning or split dose
✓ Improves absorption and reduces GI discomfort
Increases venous tone, reduces capillary permeability, and improves lymphatic drainage.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
B · Strong evidence in hemorrhoid acute treatment and CVI symptom relief. Most evidence from European trials of Daflon-branded MPFF — generic versions may differ in bioavailability.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: See richResearch section for study filters and participant data. Clinical evidence summarised from peer-reviewed journals.
How to use Diosmin Hesperidin specifically for Venous insufficiency — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Diosmin Hesperidin — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Diosmin Hesperidin — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Diosmin Hesperidin — context the structured blocks above don't capture.
Combination of two citrus flavonoids — diosmin (450 mg) and hesperidin (50 mg) — typically in micronized purified flavonoid fraction (MPFF). Branded as Daflon in France; available as Detralex and other names in EU. Pharmaceutical-grade in many countries, supplement-grade in others including India.
Increases venous tone, reduces capillary permeability, and improves lymphatic drainage. Micronization (sub-2-micron particle size) dramatically improves bioavailability — non-micronized versions have weaker effects. Reduces inflammation markers in venous walls.
The evidence base (B+ grade) reflects this: Strong evidence in hemorrhoid acute treatment and CVI symptom relief. Most evidence from European trials of Daflon-branded MPFF — generic versions may differ in bioavailability. For practical use, the typical dose range is 500-1000 mg daily (1000 mg twice daily during acute hemorrhoid flares for 4 days), ideally with a fat-containing meal for fat-soluble compounds.
Who benefits most: Adults with chronic venous insufficiency, hemorrhoid bleeding/symptoms, post-thrombotic syndrome, or lymphedema. Pregnancy hemorrhoids (often used in obstetrics in EU).
Cautions: Lactation (limited data). Concurrent strong anticoagulants. Some interactions with calcium channel blockers reported.
Pairing notes: Horse chestnut for combined venous support. Vitamin C for flavonoid synergy.
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