Aesculus hippocastanum · Aescin · Venostatin
300 mg · vegan · gluten-free · 60 caps
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Standardized extract of horse chestnut seeds (Aesculus hippocastanum), with aescin (escin) as the marker compound — typically 50-75 mg aescin per dose. CRITICAL: raw horse chestnut seeds are toxic; only standardized extracts (Venostatin Retard, Venocur) are safe.
Aescin reduces vascular permeability, increases venous tone, and inhibits enzymes that degrade vein-wall proteoglycans. This translates to less fluid leakage into surrounding tissue (the cause of leg edema) and improved venous return.
Adults with chronic venous insufficiency, leg edema not due to heart/kidney failure, varicose veins, post-surgical edema, and pregnancy-related leg swelling (with doctor approval).
DO NOT use raw horse chestnut seeds — toxic. Pregnancy/breastfeeding without medical supervision. Bleeding disorders. Kidney disease. Diabetics on hypoglycemic medications (rare cases of hypoglycemia reported).
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✓ Morning or split dose
✓ Improves absorption and reduces GI discomfort
Aescin reduces vascular permeability, increases venous tone, and inhibits enzymes that degrade vein-wall proteoglycans.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
B · Cochrane review confirmed effectiveness for CVI. Strong evidence relative to most herbal supplements. Standardization to aescin is essential.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: See richResearch section for study filters and participant data. Clinical evidence summarised from peer-reviewed journals.
How to use Horse Chestnut Extract specifically for Chronic venous insufficiency — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Horse Chestnut Extract — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Horse Chestnut Extract — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Horse Chestnut Extract — context the structured blocks above don't capture.
Standardized extract of horse chestnut seeds (Aesculus hippocastanum), with aescin (escin) as the marker compound — typically 50-75 mg aescin per dose. CRITICAL: raw horse chestnut seeds are toxic; only standardized extracts (Venostatin Retard, Venocur) are safe.
Aescin reduces vascular permeability, increases venous tone, and inhibits enzymes that degrade vein-wall proteoglycans. This translates to less fluid leakage into surrounding tissue (the cause of leg edema) and improved venous return.
The evidence base (B+ grade) reflects this: Cochrane review confirmed effectiveness for CVI. Strong evidence relative to most herbal supplements. Standardization to aescin is essential. For practical use, the typical dose range is 300 mg twice daily standardized to 50 mg aescin per dose, ideally with a fat-containing meal for fat-soluble compounds.
Who benefits most: Adults with chronic venous insufficiency, leg edema not due to heart/kidney failure, varicose veins, post-surgical edema, and pregnancy-related leg swelling (with doctor approval).
Cautions: DO NOT use raw horse chestnut seeds — toxic. Pregnancy/breastfeeding without medical supervision. Bleeding disorders. Kidney disease. Diabetics on hypoglycemic medications (rare cases of hypoglycemia reported).
Pairing notes: Diosmin-hesperidin for additional venous support. Vitamin C for collagen.
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