Arginine Alpha-Ketoglutarate · L-arginine α-ketoglutarate
1000 mg · vegan · gluten-free · 60 caps
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L-arginine bound to alpha-ketoglutarate (AKG), a TCA cycle intermediate. The pairing claims better bioavailability than plain L-arginine, which has notoriously low oral absorption (<1% systemic). AKG itself has independent longevity research (Buck Institute), but that's not the marketed mechanism here.
Arginine is the substrate for nitric oxide synthase (NOS) producing NO for vasodilation. Problem: oral arginine has poor bioavailability due to intestinal arginase. AKG binding may help slightly but doesn't solve the fundamental issue. L-citrulline (which converts to arginine in kidneys, bypassing intestinal arginase) has better evidence for NO availability.
Pre-workout supplementation seekers. Adults investigating arginine pathway support. People who prefer arginine over citrulline form for personal reasons.
Herpes flare-history (arginine can trigger HSV reactivation in some). Concurrent nitrate medications. Asthma (case reports of bronchospasm with high-dose arginine). Hypotension medications without monitoring.
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No full stack configured.
Click individual supplement pills above to buy each on Amazon India.
✓ Morning or split dose
✓ Improves absorption and reduces GI discomfort
Arginine is the substrate for nitric oxide synthase (NOS) producing NO for vasodilation.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Chronic fatigue cohort (n≈55, VAS scale)
VAS fatigue scale 0–10. Lower = less fatigue.
C · Some small trials show modest performance effects. L-citrulline generally outperforms AAKG for the same intended mechanism at lower doses.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: See richResearch section for study filters and participant data. Clinical evidence summarised from peer-reviewed journals.
How to use AAKG specifically for Athletic performance — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of AAKG — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about AAKG — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on AAKG — context the structured blocks above don't capture.
L-arginine bound to alpha-ketoglutarate (AKG), a TCA cycle intermediate. The pairing claims better bioavailability than plain L-arginine, which has notoriously low oral absorption (<1% systemic). AKG itself has independent longevity research (Buck Institute), but that’s not the marketed mechanism here.
Arginine is the substrate for nitric oxide synthase (NOS) producing NO for vasodilation. Problem: oral arginine has poor bioavailability due to intestinal arginase. AKG binding may help slightly but doesn’t solve the fundamental issue. L-citrulline (which converts to arginine in kidneys, bypassing intestinal arginase) has better evidence for NO availability.
The evidence base (C+ grade) reflects this: Some small trials show modest performance effects. L-citrulline generally outperforms AAKG for the same intended mechanism at lower doses. For practical use, the typical dose range is 3000-6000 mg pre-workout, ideally with a fat-containing meal for fat-soluble compounds.
Who benefits most: Pre-workout supplementation seekers. Adults investigating arginine pathway support. People who prefer arginine over citrulline form for personal reasons.
Cautions: Herpes flare-history (arginine can trigger HSV reactivation in some). Concurrent nitrate medications. Asthma (case reports of bronchospasm with high-dose arginine). Hypotension medications without monitoring.
Pairing notes: Citrulline malate for combined NO pathways. Beetroot extract.
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