PLC · GPLC (glycine propionyl-L-carnitine) · L-carnitine propionyl
500 mg · vegan · gluten-free · 60 caps
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L-carnitine bound to propionic acid. Different from base L-carnitine (general energy) and acetyl-L-carnitine (brain-targeted, ALCAR). The propionyl group provides additional substrate for the TCA cycle and shows more affinity for cardiac and vascular tissues.
Like other carnitines, transports long-chain fatty acids into mitochondria for beta-oxidation. The propionyl moiety enters the TCA cycle directly via propionyl-CoA → succinyl-CoA. The vascular preference may explain peripheral artery disease (PAD) walking distance improvements seen in trials.
Adults with PAD or intermittent claudication, congestive heart failure patients, men with vascular-origin erectile dysfunction (combination with sildenafil shown synergistic in small trials).
End-stage kidney disease (carnitine clearance issues). Concurrent thyroid hormone supplementation (potential interaction). Pregnancy without medical oversight.
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✓ Morning or split dose
✓ Improves absorption and reduces GI discomfort
Like other carnitines, transports long-chain fatty acids into mitochondria for beta-oxidation.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
B · Moderate evidence in PAD walking distance. Cardiovascular benefit better-supported than performance/longevity claims.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Ventura 2016 (selenium thyroid meta-analysis), Wichman 2016 (Anti-TPO reduction RCT). richResearch section contains study filters.
How to use Propionyl L-Carnitine specifically for Intermittent claudication — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Propionyl L-Carnitine — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Propionyl L-Carnitine — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Propionyl L-Carnitine — context the structured blocks above don't capture.
L-carnitine bound to propionic acid. Different from base L-carnitine (general energy) and acetyl-L-carnitine (brain-targeted, ALCAR). The propionyl group provides additional substrate for the TCA cycle and shows more affinity for cardiac and vascular tissues.
Like other carnitines, transports long-chain fatty acids into mitochondria for beta-oxidation. The propionyl moiety enters the TCA cycle directly via propionyl-CoA → succinyl-CoA. The vascular preference may explain peripheral artery disease (PAD) walking distance improvements seen in trials.
The evidence base (B- grade) reflects this: Moderate evidence in PAD walking distance. Cardiovascular benefit better-supported than performance/longevity claims. For practical use, the typical dose range is 500 mg 2-3 times daily for vascular indications, ideally with a fat-containing meal for fat-soluble compounds.
Who benefits most: Adults with PAD or intermittent claudication, congestive heart failure patients, men with vascular-origin erectile dysfunction (combination with sildenafil shown synergistic in small trials).
Cautions: End-stage kidney disease (carnitine clearance issues). Concurrent thyroid hormone supplementation (potential interaction). Pregnancy without medical oversight.
Pairing notes: Ubiquinol for cardiac energy support. L-arginine for vascular function.
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