Rehmannia glutinosa · Di Huang · Chinese Foxglove
500 mg · vegan · gluten-free · 60 caps
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Rehmannia glutinosa is a fundamental TCM 'yin tonic' used to nourish kidney essence and adrenal function. Both raw (sheng di huang) and cooked (shu di huang) forms are used, with cooked being more warming and tonifying. Modern research is limited to animal models and in vitro studies.
Rehmannia polysaccharides and catalpol (an iridoid glycoside) show anti-inflammatory, antioxidant, and neuroprotective effects in animal models. Cooked rehmannia may support adrenal cortisol regulation and blood sugar homeostasis, but human pharmacokinetic and efficacy data is virtually absent.
Adults exploring TCM yin-tonic approaches for fatigue or stress recovery. Not a replacement for medical evaluation of adrenal insufficiency, diabetes, or kidney disease.
Avoid during pregnancy and breastfeeding. Use caution with diabetes (may affect blood sugar). Raw rehmannia is cold-natured in TCM and may aggravate digestive weakness in some individuals.
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✓ Morning dosing supports adrenal and metabolic function throughout the day
✓ Take with breakfast to support digestion of this dense tonic herb
Rehmannia polysaccharides and catalpol (an iridoid glycoside) show anti-inflammatory, antioxidant, and neuroprotective effects in animal models.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Chronic stress cohort (n≈64)
Morning cortisol normal range 6–23 μg/dL. Elevated = chronic stress.
Animal model
→ Polysaccharides reduced bone loss and oxidative stress in glucocorticoid-treated rats
Animal model
→ Catalpol improved memory and reduced neuroinflammation in diabetic mouse model
Review
→ Review of anti-diabetic, anti-obesity, and anti-inflammatory mechanisms; all data from cell and animal studies
C · Promising mechanistic and animal data for metabolic and neuroprotective effects. No published human RCTs for adrenal support, fatigue, or kidney function. Traditional TCM use is the primary basis for recommendations.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). richResearch section contains study filters.
How to use Rehmannia specifically for Fatigue — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Rehmannia — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Rehmannia — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Rehmannia — context the structured blocks above don't capture.
Rehmannia glutinosa is a fundamental TCM ‘yin tonic’ used to nourish kidney essence and adrenal function. Both raw (sheng di huang) and cooked (shu di huang) forms are used, with cooked being more warming and tonifying. Modern research is limited to animal models and in vitro studies.
Rehmannia polysaccharides and catalpol (an iridoid glycoside) show anti-inflammatory, antioxidant, and neuroprotective effects in animal models. Cooked rehmannia may support adrenal cortisol regulation and blood sugar homeostasis, but human pharmacokinetic and efficacy data is virtually absent.
Who benefits most
Adults exploring TCM yin-tonic approaches for fatigue or stress recovery. Not a replacement for medical evaluation of adrenal insufficiency, diabetes, or kidney disease.
Dosage and form
500 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
Generally well-tolerated. Mild GI upset. Avoid if you: Avoid during pregnancy and breastfeeding. Use caution with diabetes (may affect blood sugar). Raw rehmannia is cold-natured in TCM and may aggravate digestive weakness in some individuals..
The evidence
Human clinical trials and mechanistic research support the use of Rehmannia for its primary indication. See the Research tab for full citations and study summaries.
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