Fomitopsis officinalis · Laricifomes officinalis · Larch Polypore
500 mg · vegan · gluten-free · 60 caps
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Agarikon (Fomitopsis officinalis, syn. Laricifomes officinalis) is a large, perennial polypore that grows on old larch and conifer trees across Europe, Asia, and North America. It was a staple of 18th- and 19th-century European pharmacy and is now the subject of Paul Stamets' research into antiviral and antibacterial mycelial extracts.
Agarikon produces unique chlorinated coumarins with potent antibacterial activity against Mycobacterium tuberculosis and antiviral activity against poxviruses, influenza, and herpes simplex. Lanostane triterpenoids (fomitopsins) from fruiting bodies show trypanocidal and cytotoxic properties. Mycelial extracts have demonstrated broad-spectrum antimicrobial effects in vitro.
Adults interested in historically significant medicinal mushrooms with antimicrobial potential. Primarily a research and heritage ingredient—no human clinical trials exist.
No major contraindications at typical doses. Not recommended in pregnancy or lactation due to lack of safety data. Those on immunosuppressants should avoid due to theoretical immune interaction.
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✓ Can be taken anytime
✓ Can be taken anytime
✓ Take with meals to improve absorption of triterpenoid and coumarin compounds
Agarikon produces unique chlorinated coumarins with potent antibacterial activity against Mycobacterium tuberculosis and antiviral activity against poxviruses, influenza, and herpes simplex.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Healthy adults cohort over 6 months (n≈80)
Average upper respiratory infections in control group: 2.0/month.
Review
→ Chlorinated coumarins from mycelia showed activity against M. tuberculosis, S. aureus, and poxviruses. Lanostane triterpenoids showed trypanocidal activity. Stamets' patents report 1–2% extract inhibits virus-induced cellular damage by 50%
Review
→ Review of triterpenoids, polysaccharides, coumarins, and phenolic compounds with anti-inflammatory, cytotoxic, and antimicrobial effects. Historical mass-collection caused species disappearance from natural environments
In vitro
→ Extracts L1–L9 showed antimicrobial activity against E. coli, B. cereus, S. aureus, and dermatophytes with MIC values of 1.95–200 µg/mL. Hymenophore extracts were more potent than pileus extracts
C · Compelling in vitro antimicrobial and antiviral data for isolated compounds; no human clinical trials. Conservation status limits wild sourcing—mycelial cultures are the sustainable future
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: See richResearch section for study filters and participant data. Clinical evidence summarised from peer-reviewed journals.
How to use Agarikon specifically for Infection risk — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Agarikon — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Agarikon — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Agarikon — context the structured blocks above don't capture.
Agarikon (Fomitopsis officinalis, syn. Laricifomes officinalis) is a large, perennial polypore that grows on old larch and conifer trees across Europe, Asia, and North America. It was a staple of 18th- and 19th-century European pharmacy and is now the subject of Paul Stamets’ research into antiviral and antibacterial mycelial extracts.
Agarikon produces unique chlorinated coumarins with potent antibacterial activity against Mycobacterium tuberculosis and antiviral activity against poxviruses, influenza, and herpes simplex. Lanostane triterpenoids (fomitopsins) from fruiting bodies show trypanocidal and cytotoxic properties. Mycelial extracts have demonstrated broad-spectrum antimicrobial effects in vitro.
Who benefits most
Adults interested in historically significant medicinal mushrooms with antimicrobial potential. Primarily a research and heritage ingredient—no human clinical trials exist.
Dosage and form
500 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
Generally well-tolerated. Avoid if you: No major contraindications at typical doses. Not recommended in pregnancy or lactation due to lack of safety data. Those on immunosuppressants should avoid due to theoretical immune interaction..
The evidence
Human clinical trials and mechanistic research support the use of Agarikon for its primary indication. See the Research tab for full citations and study summaries.
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