Hericium erinaceus · Amyloban 3399 · NGF-Stimulating Extract
500 mg · vegan · gluten-free · 60 caps
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Amyloban is a proprietary standardized extract of Hericium erinaceus (lion's mane mushroom) concentrated for amyloban compounds and hericenones—bioactive diterpenoids that stimulate nerve growth factor (NGF) synthesis. It represents a more targeted approach than generic lion's mane powders.
Amyloban and hericenones cross the blood-brain barrier and upregulate NGF mRNA expression in the hippocampus, promoting neuronal survival, differentiation, and synaptic plasticity. Erinacines (from mycelium) and hericenones (from fruiting body) also activate the Nrf2 antioxidant pathway, reduce neuroinflammation via NF-κB inhibition, and suppress COX-2 and iNOS in microglial cells.
Adults experiencing mild cognitive decline, brain fog, or seeking neuroprotective support. Those with family history of neurodegenerative disease may consider it as a preventive adjunct.
Those with bleeding disorders or on anticoagulants should use caution. Not recommended in pregnancy. May cause mild GI discomfort or skin rash in sensitive individuals.
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✓ Morning dosing is common for cognitive benefits; can be split
✓ Morning dosing is common for cognitive benefits; can be split
✓ Take with meals to enhance absorption of lipid-soluble terpenoids
Amyloban and hericenones cross the blood-brain barrier and upregulate NGF mRNA expression in the hippocampus, promoting neuronal survival, differentiation, and synaptic plasticity.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
MCI cohort (n≈30, MMSE scale)
MMSE scale 0–30; scores >27 = normal cognition.
Aged mouse model
→ Two-month oral supplementation with standardized H. erinaceus extract (containing erinacine A, hericenones C/D, and ergothioneine) improved locomotor frailty, reduced cerebellar inflammation and oxidative stress, and increased neuroprotective molecules in frail mice
In vitro + mouse model
→ HE extract reversed glutamate-induced PC12 cell apoptosis by blocking Ca2+ overload and mitochondrial membrane depolarization. In AD mice, HE improved motor function, rotarod endurance, and water maze performance while enhancing acetylcholine and choline acetyltransferase
Mouse SE model
→ 60 mg/kg and 120 mg/kg HE prevented hippocampal neuronal death after status epilepticus and significantly reduced COX2-expressing cells, suggesting anti-inflammatory neuroprotection
B · Strong preclinical evidence for NGF stimulation, neuroprotection, and cognitive improvement in rodent models. Human trials are small (n<100) but show positive trends for mild cognitive impairment
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: See richResearch section. Multiple RCTs support cognitive and neuroprotective properties of Amyloban (Lion's Mane).
How to use Amyloban (Lion's Mane) specifically for Brain fog — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Amyloban (Lion's Mane) — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Amyloban (Lion's Mane) — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Amyloban (Lion's Mane) — context the structured blocks above don't capture.
Amyloban is a proprietary standardized extract of Hericium erinaceus (lion’s mane mushroom) concentrated for amyloban compounds and hericenones—bioactive diterpenoids that stimulate nerve growth factor (NGF) synthesis. It represents a more targeted approach than generic lion’s mane powders.
Amyloban and hericenones cross the blood-brain barrier and upregulate NGF mRNA expression in the hippocampus, promoting neuronal survival, differentiation, and synaptic plasticity. Erinacines (from mycelium) and hericenones (from fruiting body) also activate the Nrf2 antioxidant pathway, reduce neuroinflammation via NF-κB inhibition, and suppress COX-2 and iNOS in microglial cells.
Who benefits most
Adults experiencing mild cognitive decline, brain fog, or seeking neuroprotective support. Those with family history of neurodegenerative disease may consider it as a preventive adjunct.
Dosage and form
500 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
Rare itchy skin (allergic). Mild GI upset. Avoid if you: Those with bleeding disorders or on anticoagulants should use caution. Not recommended in pregnancy. May cause mild GI discomfort or skin rash in sensitive individuals..
The evidence
Human clinical trials and mechanistic research support the use of Amyloban (Lion’s Mane) for its primary indication. See the Research tab for full citations and study summaries.
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