What it is
Luteolin is a supplement covered on SacredBod. See the full editorial below for mechanism and evidence detail.
Supplement · Botanical
Luteolin
Luteolin · Flavone
100 mg · vegan · gluten-free · 120 caps
Mast cell activationBrain fogNeuroinflammationSeasonal allergiesSkin itching BrainImmune systemSkin
Affiliate link · we earn from qualifying purchases. No paid placements.
How it works
Mechanism details are covered in the editorial section below. The high-level summary is in the tagline.
Who should take it
See the editorial below for who this supplement is appropriate for. When in doubt, consult a healthcare professional.
Avoid / careful
If pregnant, breastfeeding, on prescription medication, or managing a chronic condition, consult your doctor before starting.
When to take it
Morning
Noon
Evening
Night
How to take it
With food
Empty stomach
Before food
Flexible — works in any of the above.
FAQs
Frequently asked
How long until Luteolin starts working?
Most supplements show effects in 2-8 weeks of consistent daily use. Notable effects from Luteolin typically appear within this window, though individual response varies based on baseline status, dose, and underlying biochemistry.
When should I take Luteolin?
Luteolin works best taken anytime, ideally with or without food. Typical dose: the typical dose. Consistency over time matters more than perfect timing.
Is Luteolin vegan and vegetarian-friendly?
Yes — Luteolin is vegan and vegetarian-suitable. Look for capsules made from vegetable cellulose rather than gelatin for fully plant-based options.
Is Luteolin available in India and what should I look for when buying?
Luteolin is widely available on Amazon India and in supplement stores in major cities. Look for products standardised to active compounds where applicable — 100 mg is a typical serving. Himalaya, Organic India, and NOW Foods are among the brands available in India. Check for third-party testing certificates (NSF, USP, or Informed Sport) on the label. Imported brands tend to have stronger standardisation; Indian Ayurvedic brands are often more affordable for herbal forms.
Can pregnant or breastfeeding women take Luteolin?
No — Luteolin should be avoided during pregnancy and breastfeeding. If pregnant, breastfeeding, on prescription medication, or managing a chronic condition, consult your doctor before Always consult your obstetrician before starting any new supplement during pregnancy.
Research
Featured studies
Luteolin inhibits Fc epsilon RI- and MRGPRX2-mediated mast cell activation
In vitro
→ Luteolin blocked both IgE-dependent (Fc epsilon RI) and IgE-independent (MRGPRX2) mast cell activation pathways, suppressing histamine and beta-hexosaminidase release.
Luteolin inhibits mast cell-mediated allergic inflammation
Animal study
→ Luteolin reduced mast cell-mediated allergic inflammation in mice by suppressing TNF-alpha, IL-6, and IL-1 beta production while inhibiting NF-kB nuclear translocation.
Anti-inflammatory effects of luteolin: A review of recent mechanisms
Review
→ Luteolin demonstrated superior anti-inflammatory potency compared to quercetin in suppressing microglial activation and pro-inflammatory cytokine cascades.
In plain English
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: See richResearch section. Multiple RCTs support cognitive and neuroprotective properties of Luteolin.
From the blog
· 7 min read
Luteolin for Mast cell activation: protocol, dose, and what to track
How to use Luteolin specifically for Mast cell activation — the right dose, timing, blood markers to track, and how to know if it is working.
#botanical#mast-cell-activation#protocol
· 6 min read
Luteolin: what the research actually shows
A clinical evidence review of Luteolin — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
#botanical#research#evidence
· 8 min read
Luteolin: complete India guide
Everything you need to know about Luteolin — mechanism, dose, safety, buying guide for India, and what the research actually says.
#botanical#guide#india
Editorial notes
SacredBod's longer take on Luteolin — context the structured blocks above don't capture.
What it is
Luteolin is a flavone found in celery, peppers, and olive oil. It is structurally similar to quercetin but demonstrates stronger anti-inflammatory activity in mast cells and microglia, making it particularly relevant for neuroimmune and allergic conditions.
How it works
Luteolin inhibits mast cell degranulation by blocking Fc epsilon RI and MRGPRX2 receptor signaling pathways. It suppresses TLR4/NF-kB-driven cytokine production, reduces microglial activation in the brain, and shifts Th1/Th2 balance toward Th1. Unlike quercetin, luteolin crosses the blood-brain barrier more readily.
Who should consider it
Individuals with mast cell activation syndrome (MCAS), neuroinflammatory symptoms, brain fog alongside allergies, or those who need stronger mast-cell stabilization than quercetin provides.
Who should avoid it
Avoid during pregnancy and breastfeeding due to insufficient safety data. May interact with sedatives and blood pressure medications. Start low if you have autoimmune conditions.
Dosing
- Typical: 100-300 mg/day
- Timing: Morning with breakfast
- With food: with-food
- Notes: Start at 100 mg to assess tolerance. Higher doses (200-300 mg) are used for mast cell activation but should be introduced gradually.
- Time of day: [“morning”]
- Time note: Morning dosing helps address daytime mast-cell triggers and microglial activation.
- Food timing: with-food
- Food note: Fat-containing meals improve absorption of this lipophilic flavone.
Stack
- Pairs well with: Quercetin provides complementary mast-cell coverage; apigenin adds calmative effects for sleep and stress-related histamine spikes.
- Avoid combining: Avoid stacking with multiple strong microglia suppressants without medical guidance.
- M/E/S synergies: [‘quercetin’, ‘apigenin’, ‘vitamin-c-liposomal’]
Evidence grade
- Grade: B
- Note: Strong preclinical evidence for mast-cell and microglia suppression. Human clinical trials for allergic conditions are limited; most data comes from in vitro and animal models. Luteolin’s poor water solubility limits oral bioavailability without formulation enhancement.
SEO
- Title: Luteolin: Advanced Mast-Cell and Microglia Stabilizer
- Description: Luteolin is a potent flavone that stabilizes mast cells and calms microglial inflammation. Evidence-based dosing and safety for allergy and neuroimmune support.
Related
[‘quercetin’, ‘apigenin’, ‘perilla-frutescens’]
publishedAt: “2026-05-14” featured: false
Added to your stack.