Yohimbe bark extract · Pausinystalia yohimbe · Corynanthe yohimbe
5 mg · vegan · gluten-free · 60 caps
Affiliate link · we earn from qualifying purchases. No paid placements.
Yohimbine is an indole alkaloid derived from the bark of the African yohimbe tree (Pausinystalia yohimbe). As a prescription drug, it has been used for decades to treat erectile dysfunction. As a dietary supplement (yohimbine HCl), it is sold for erectile support and fat loss but carries significant cardiovascular and psychiatric side effect risks.
Yohimbine is a selective alpha-2 adrenergic receptor antagonist. By blocking alpha-2 receptors in the central nervous system and peripheral blood vessels, it increases norepinephrine release, enhances sympathetic outflow, and promotes penile blood flow via nitric oxide pathways. The same mechanism explains its stimulant and anxiety-inducing effects.
Men with psychogenic erectile dysfunction or those seeking fat-loss adjuncts who have no history of anxiety, hypertension, or cardiac arrhythmia. Absolutely contraindicated in men with cardiovascular disease, anxiety disorders, or those taking MAO inhibitors.
Do NOT use if you have hypertension, heart disease, anxiety disorders, bipolar disorder, PTSD, or are taking MAO inhibitors, SSRIs, or stimulants. Can cause rapid heartbeat, elevated blood pressure, sweating, tremors, and panic attacks. Start with the lowest possible dose.
Pick a depth — minimum to maximal coverage
No full stack configured.
Click individual supplement pills above to buy each on Amazon India.
✓ Morning dosing preferred; avoid evening use due to insomnia and overstimulation risk
Flexible — works in any of the above.
Yohimbine is a selective alpha-2 adrenergic receptor antagonist.
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Stage 1 hypertension cohort (n≈70)
Target systolic BP <130 mmHg (ACC/AHA 2017 guidelines).
18
→ Dose-escalation trial in men with organic ED: 34% achieved partial erections sufficient for intercourse at doses of 15-25 mg/day.
48
→ Double-blind RCT: yohimbine significantly improved erectile function versus placebo in men with psychogenic ED; anxiety and elevated BP were common side effects.
Meta-analysis (7 RCTs)
→ Meta-analysis of 7 RCTs found yohimbine superior to placebo (OR 3.85) for erectile dysfunction; adverse effects were infrequent and reversible.
B · Multiple RCTs and a meta-analysis support efficacy for psychogenic and mild organic ED. However, side effect profile (anxiety, hypertension, tachycardia) is substantial and limits real-world utility. Effect size is modest and dropout rates in trials are non-trivial.
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: See richResearch section. Multiple RCTs support cognitive and neuroprotective properties of Yohimbine HCl.
How to use Yohimbine HCl specifically for Erectile dysfunction — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Yohimbine HCl — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Yohimbine HCl — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Yohimbine HCl — context the structured blocks above don't capture.
Yohimbine is one of the few dietary supplement ingredients with genuine prescription-level pharmacology — and that is both its strength and its danger. Unlike most “natural ED remedies” that rely on vague mechanisms, yohimbine has a well-defined receptor target, measurable physiological effects, and a side effect profile that can be genuinely harmful.
The 1998 meta-analysis by Ernst and Pittler synthesized seven randomized placebo-controlled trials of yohimbine monotherapy for erectile dysfunction. The pooled odds ratio was 3.85 in favor of yohimbine — a clinically meaningful effect. However, the authors noted that the individual trials were small, short in duration, and enrolled mixed populations of psychogenic and organic ED patients.
The 1997 Vogt study specifically tested yohimbine in 48 men with psychogenic ED using a double-blind, placebo-controlled design. Yohimbine produced significantly better erectile function scores than placebo, but anxiety and elevated blood pressure were common enough that the authors cautioned against casual use.
The 2002 Guay study took a different angle, testing dose escalation (up to 25 mg/day) in 18 men with organic ED. Only 34% achieved partial erections sufficient for intercourse — a reminder that yohimbine is far less effective when vascular or neurological damage is present. In severe organic ED, PDE5 inhibitors (sildenafil, tadalafil) are vastly superior.
Yohimbine is also marketed for fat loss because alpha-2 antagonism increases lipolysis in adipose tissue — particularly in “stubborn” fat areas like the lower abdomen and thighs in men. Human evidence is limited but suggests a modest effect when taken in a fasted state before aerobic exercise. The same cardiovascular and anxiety risks apply, making this a poor choice for most recreational users.
Yohimbine’s side effects are dose-dependent and unpredictable:
These are not rare “idiosyncratic” reactions — they are mechanistically expected consequences of alpha-2 blockade and norepinephrine release. Men with pre-existing anxiety or hypertension are playing with fire.
For erectile dysfunction, PDE5 inhibitors (prescription sildenafil/tadalafil) are more effective, more predictable, and in many cases safer than yohimbine. For a natural approach with fewer risks, L-citrulline (nitric oxide support) or tongkat ali (testosterone support) are better first-line options. Yohimbine should be reserved for men who have failed safer alternatives, have no cardiovascular or psychiatric contraindications, and are willing to accept significant side effect risk.
Peptides are physician-only. Tell us a bit and we'll route you to the right specialist.
