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Senolytic Adjunct Support supplement stack (illustrative)
Stack · Longevity & NAD+

Senolytic Adjunct Support

Supporting the clearance of senescent cells.

Cellular senescenceAge-related dysfunctionLongevity goals
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Quick facts
  • 10 supplements
  • Evidence: C
  • 1/5/10 tier picker

Pick your depth

Same stack, three commitment levels.

FULL
10 supplements · max coverage
Senolytic Combo (Fisetin + Quercetin)Fisetin (Senolytic Pulse)Quercetin (Senolytic High Dose)Fisetin High Dose (500 mg)Quercetin Phytosome (Quercefit)ErgothioneineAlpha-Ketoglutarate PureUrolithin A (Mitophagy)NMN High Dose (1 g)Fisetin
BUY Senolytic Combo (Fisetin + Quercetin) → BUY Fisetin (Senolytic Pulse) → BUY Quercetin (Senolytic High Dose) → BUY Fisetin High Dose (500 mg) → BUY Quercetin Phytosome (Quercefit) → BUY Ergothioneine → BUY Alpha-Ketoglutarate Pure → BUY Urolithin A (Mitophagy) → BUY NMN High Dose (1 g) → BUY Fisetin →
Overview Symptoms & markers

Aims to complement senolytic therapies by providing compounds that may support the body's natural processes for clearing senescent cells.

What it's for

This stack includes compounds like Quercetin and Fisetin, known for their senolytic properties, alongside supportive nutrients to aid in the removal of aged and dysfunctional cells.

Not for:This is an adjunct support and not a standalone senolytic therapy. Consult with a knowledgeable practitioner.

Symptoms it can address

✓ Cellular senescence✓ Age-related dysfunction✓ Longevity goals
Evidence grade
ABCD

C · Pooled evidence for the stack as a whole. Individual supplements may have stronger or weaker grades — see their pages.

Members of the FULL stack

  1. Senolytic Combo (Fisetin + Quercetin)

    Specialty & Senolytic · As directed (cyclic)

    Combines Fisetin and Quercetin, the primary senolytic agents, for synergistic clearance of senescent cells.

    Details BUY →

  2. Fisetin (Senolytic Pulse)

    Longevity & Senolytic · 500 mg–1500 mg in 2-day pulses (monthly)

    Provides a high dose of Fisetin, a key senolytic compound, for potent support in clearing aged cells.

    Details BUY →

  3. Quercetin (Senolytic High Dose)

    Longevity & Senolytic · 1000 mg

    Offers a high dose of Quercetin, a foundational senolytic, to aid in the removal of senescent cells.

    Details BUY →

  4. Fisetin High Dose (500 mg)

    Longevity & Senolytic · 500 mg

    Supplements Fisetin at a significant dose, contributing to the senolytic effect and cellular rejuvenation.

    Details BUY →

  5. Quercetin Phytosome (Quercefit)

    Longevity & Senolytic · 250–500 mg phytosome

    Delivers Quercetin in a highly bioavailable form, enhancing its senolytic activity and cellular support.

    Details BUY →

  6. Ergothioneine

    Antioxidants · 5 mg

    Acts as a potent antioxidant, protecting cells during the senolytic process and supporting overall cellular health.

    Details BUY →

  7. Alpha-Ketoglutarate Pure

    Epigenetic Longevity · 500 mg

    Supports mitochondrial function and cellular energy, crucial for the efficient clearance of senescent cells.

    Details BUY →

  8. Urolithin A (Mitophagy)

    Longevity & Mitochondrial · 500 mg

    Promotes mitophagy, the selective removal of damaged mitochondria, aiding cellular quality control during senolysis.

    Details BUY →

  9. NMN High Dose (1 g)

    Longevity & NAD+ · 1000 mg

    Boosts NAD+ levels, vital for cellular repair and energy metabolism, supporting the body's response to senescent cell clearance.

    Details BUY →

  10. Fisetin

    Senolytic & Longevity · 100 mg

    Adjunct support for the Senolytic Adjunct Support protocol.

    Details BUY →

Ready to build your stack?

4–8 weeks to feel the full benefit. Start with MES if you're new — that's where most people land.

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