Ca-AKG · Calcium AKG · α-Ketoglutaric Acid
1,000 mg · vegan · gluten-free · 60 caps
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Calcium alpha-ketoglutarate (Ca-AKG) is the calcium salt of α-ketoglutarate, a key intermediate in the TCA cycle and a substrate for DNA/RNA demethylases. It serves as a nitrogen transporter, a precursor for glutamine, glutamate, and collagen, and a signaling molecule that regulates mTOR and inflammatory pathways.
Ca-AKG suppresses chronic systemic inflammation by inducing IL-10, an anti-inflammatory cytokine that counteracts the senescence-associated secretory phenotype (SASP). In aged mice, late-onset dietary Ca-AKG reduced inflammatory cytokines, decreased frailty scores, and extended median lifespan by ~12%. It also stabilizes redox homeostasis and improves arterial elasticity in aging organisms.
Adults over 40 seeking metabolic longevity support, or those with low bone density wanting a collagen synthesis precursor.
No major contraindications at typical doses. Those with kidney stones should use caution (oxalate metabolism theoretical concern). Not recommended in pregnancy.
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✓ Split dosing may improve absorption and reduce GI discomfort
✓ Split dosing may improve absorption and reduce GI discomfort
✓ Take with meals to improve absorption and minimize stomach upset
Ca-AKG suppresses chronic systemic inflammation by inducing IL-10, an anti-inflammatory cytokine that counteracts the senescence-associated secretory phenotype (SASP).
Each bar = one cited trial. Effect varies by methodology, dose, and population.
Representative cohort from published RCT data
Relative to baseline (100). Data from published clinical literature.
C57BL/6 mice
→ Late-onset Ca-AKG supplementation promoted longer, healthier life with decreased systemic inflammatory cytokines. Induction of IL-10 suppressed chronic inflammation and SASP, compressing morbidity
12-month-old mice
→ Ca-AKG significantly increased total antioxidant status (TAS), decreased TBARS in blood and liver, and improved arterial elastic characteristics in elderly mice compared to age-matched controls
Commentary
→ Review highlights critical links between metabolism, inflammation, and aging; notes Ca-AKG as a key longevity metabolite alongside NAD+ and spermidine
B · Landmark mouse longevity study with robust methodology; human clinical trials for lifespan extension are absent. Bone health and metabolic benefits in humans are extrapolated from shorter-term studies
A plain-English read of the literature behind this supplement. Not a clinical recommendation.
Key citations: Abenavoli 2010 (hepatoprotection systematic review), Cacciapuoti 2013 (NAFLD RCT). richResearch section contains study filters.
How to use Calcium Alpha-Ketoglutarate specifically for Age related frailty — the right dose, timing, blood markers to track, and how to know if it is working.
A clinical evidence review of Calcium Alpha-Ketoglutarate — RCT data, effect sizes, evidence grade, and what the numbers mean for your specific situation.
Everything you need to know about Calcium Alpha-Ketoglutarate — mechanism, dose, safety, buying guide for India, and what the research actually says.
SacredBod's longer take on Calcium Alpha-Ketoglutarate — context the structured blocks above don't capture.
Calcium alpha-ketoglutarate (Ca-AKG) is the calcium salt of α-ketoglutarate, a key intermediate in the TCA cycle and a substrate for DNA/RNA demethylases. It serves as a nitrogen transporter, a precursor for glutamine, glutamate, and collagen, and a signaling molecule that regulates mTOR and inflammatory pathways.
Ca-AKG suppresses chronic systemic inflammation by inducing IL-10, an anti-inflammatory cytokine that counteracts the senescence-associated secretory phenotype (SASP). In aged mice, late-onset dietary Ca-AKG reduced inflammatory cytokines, decreased frailty scores, and extended median lifespan by ~12%. It also stabilizes redox homeostasis and improves arterial elasticity in aging organisms.
Who benefits most
Adults over 40 seeking metabolic longevity support, or those with low bone density wanting a collagen synthesis precursor.
Dosage and form
1,000 mg is the typical effective range. Forms matter: choose standardised extracts or highly bioavailable delivery formats (see the Forms tab). Take as directed.
Side effects and cautions
Generally well-tolerated. Mild GI upset possible in sensitive users. Rare allergic reactions in those sensitive to the plant family. Avoid if you: No major contraindications at typical doses. Those with kidney stones should use caution (oxalate metabolism theoretical concern). Not recommended in pregnancy..
The evidence
Human clinical trials and mechanistic research support the use of Calcium Alpha-Ketoglutarate for its primary indication. See the Research tab for full citations and study summaries.
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